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Integrated proteomics and metabolomics analysis reveals hubs protein and network alterations in myasthenia gravis

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机构: [1]Hebei Med Univ, Dept Anesthesiol, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China [2]Hebei Med Univ, Dept Pharm, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China [3]Hebei Med Univ, Dept Gynaecol, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
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关键词: WGCNA proteomics metabolomics gene co-expression networks myasthenia gravis

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Background: Thymoma-associated myasthenia gravis (TAMG) is a well-described subtype of Myasthenia gravis (MG). Nevertheless, the detailed proteins and bioprocess differentiating TAMG from TAMG (-) thymoma have remained unclear. Methods: The proteomics and metabolomics were carried out on serum samples from thymoma group (n = 60, TNMG), TAMG (+) thymoma group (n = 70, TAMG (+)), and TAMG (-) thymomas group (n = 62, TAMG (-)), and controls (n = 159). groups. Proteomics and metabolomics analyses, including weighted gene co-expression network analysis (WGCNA), was conducted to detect the hub proteins and metabolomics processes that could differentiate TAMG (+) from TAMG (-) thymomas. MetaboAnalyst was used to examine the integration of proteomic and metabolomic analysis to differentiate TAMG (+) from TAMG (-) thymomas. Results: The of module-trait correlation of WGCNA analysis identified KRT1, GSN, COL6A1, KRT10, FOLR2, KRT9, KRT2, TPI1, ARF3, LYZ, ADIPOQ, SEMA4B, IGKV1-27, MASP2, IGF2R was associated with TAMG (+) thymomas. In addition, organismal systems-immune system and metabolism-biosynthesis of other secondary metabolites were closely related to the mechanism of TAMG (+) pathogenesis. Conclusion: Our integrated proteomics and metabolomics analysis supply a systems-level view of proteome changes in TAMG (+), TAMG (-) thymomas and exposes disease-associated protein network alterations involved in.

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大类 | 2 区 医学
小类 | 3 区 老年医学 3 区 细胞生物学
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Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY
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第一作者机构: [1]Hebei Med Univ, Dept Anesthesiol, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
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