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The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis

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机构： [1]Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China. [2]Tumor Research Institute, The Fourth Hospital of Hebei Medical University, 050017 Shijiazhuang, Hebei, People’s Republic of China.

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Circular RNAs (circRNAs) are a type of noncoding RNA, which play a vital role in the occurrence and development of esophageal squamous cell carcinoma (ESCC). While the role of novel circADAMTS6 in ESCC remains unknown. We assessed circADAMTS6 expression in ESCC tissues and cells, and the relationship between circADAMTS6 expression and overall survival of ESCC patients. Functional experiments in vitro and xenograft in vivo assay were applied to explore the functions and mechanisms of circADAMTS6 in ESCC. Results found that up-regulation of circADAMTS6 was associated with poor overall survival and may acted as an independent risk factor for ESCC prognosis. Knockdown of circADAMTS6 significantly inhibited the proliferation, migration and invasion of ESCC cells and growth of xenograft tumors in vivo. Induced AGR2 expression was able to rescue the loss of function induced by si-circADAMTS6 in KYSE150 cell. CircADAMTS6 may acts as oncogene by activating AGR2 and the Hippo signaling pathway coactivator YAP in ESCC.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2022]版：

Q2 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 4.6 出版当年[2022版] 4.9 出版当年五年平均 4.997 出版前一年[2021版] 3.8 出版后一年[2023版]

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第一作者机构： [1]Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China.

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通讯机构： [1]Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China. [2]Tumor Research Institute, The Fourth Hospital of Hebei Medical University, 050017 Shijiazhuang, Hebei, People’s Republic of China.

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