机构：[1]Department of Neurology, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei, China[2]Department of Endocrinology, The Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China临床科室内分泌科河北医科大学第四医院[3]Department of Radiology, The Hebei Province Hospital of TCM, Shijiazhuang, Hebei, China
This study was designed to explore the role of miR-146a in diabetic retinopathy (DR). 30 healthy control (HC), 50 patients with type 2 diabetes mellitus, and 48 DR patients were enrolled. Blood was collected and levels of miR-146a expression, vascular endothelial growth factor (VEGF), and three inflammatory cytokines (NF-kappa B, IL-1 beta, and TNF-alpha) were detected. Moreover, ARPE-19 cells were treated with miR-146a mimic or inhibitor in the presence of high glucose to evaluate its effect in vitro. DR patients had the lowest level of miR-146a and the highest level of VEGF as well as the most severe inflammation among the three groups. In addition, the miR-146a level was negatively correlated with the expression of VEGF and three inflammatory cytokines, respectively in DR patients. Moreover, VEGF expression was positively correlated with these three inflammatory cytokines in DR patients. In summary, miR-146a could inhibit VEGF expression and inflammation in DR.
基金：
Youth Science and
Technology project supported by the Scientific Research
Fund of Hebei Provincial Department of
Health (20150767).
第一作者机构：[1]Department of Neurology, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei, China
通讯作者：
通讯机构：[2]Department of Endocrinology, The Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China[*1]Department of Endocrinology, The Fourth Hospital, Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang, Hebei 050000, China
推荐引用方式(GB/T 7714)：
Sun Shichao,Wang Fujun,Sun Yao,et al.miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy[J].GROWTH FACTORS.2022,40(3-4):89-97.doi:10.1080/08977194.2022.2077732.
APA：
Sun, Shichao,Wang, Fujun,Sun, Yao&Bai, Lei.(2022).miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy.GROWTH FACTORS,40,(3-4)
MLA：
Sun, Shichao,et al."miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy".GROWTH FACTORS 40..3-4(2022):89-97
