Objective: To compare the feasibility and safety of bilateral versus unilateral open-heart treatment of lung tumors by single-port Methods: Fourteen patients who underwent bilateral open-heart treatment for lung tumors at the Fourth Hospital of Hebei Medical University from August 2017 to March 2019 were collected as the observation group, and 41 patients who underwent unilateral open-heart treatment for lung tumors at the same period were randomly collected as the control group. Intraoperative circumstances, postoperative conditions, and complication rates were compared between the two groups. Results: There were no statistical differences in operative time, intraoperative bleeding, postoperative pain, intubation time, length of stay, or total lead flow rate between the two groups (p 0.05). There was no statistical difference in the number of postoperative lymph node dissections between the two groups (p 0.05). Conclusion: Single-port thoracoscopic surgery with bilateral open-heart treatment reduces the incidence of postoperative complications, facilitates lymph node dissection and does not affect the patient's length of stay, providing surgical feasibility and safety.