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SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination

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收录情况： ◇ SCIE ◇ 预警期刊

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机构： [1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, P.R. China. [2]Department of Urinary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, P.R. China.

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关键词： prostate cancer SGOL2 RAB1A ubiquitination tumor microenvironment

摘要：

Prostate cancer is the most prevalent genitourinary malignant cancer in men worldwide. Patients with prostate cancer who progress to castration-resistant prostate cancer (CRPC) or metastatic CRPC have significantly poorer survival. Advanced prostate cancer is a clinical challenge due to the lack of effective treatment strategies. In the field of oncology, SGOL2 was an emerging and differentially expressed molecule, which enhanced the proliferation of cell populations in vitro in our studies. Mass spectrum and Co-IP validated the interaction of SGOL2 and RAB1A in a protein-protein manner. We further investigated the role of SGOL2 in the regulatory mechanism of RAB1A in prostate cancer cell lines. Furthermore, SGOL2 regulated RAB1A expression by inhibiting its ubiquitination. Rescue Experiments demonstrated that SGOL2 promoted prostate cancer cell proliferation and migration by upregulating RAB1A expression. Finally, we found that SGOL2 and RAB1A may regulate the tumor microenvironment (TME) in prostate cancer. In conclusion, our findings concluded that SGOL2 stabilized RAB1A expression to promote prostate cancer development. Both of them were of great importance in TME modulation.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区老年医学 3 区细胞生物学

最新[2025]版：

无

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出版当年[2022]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.2 出版当年[2022版] 5.8 出版当年五年平均 5.955 出版前一年[2021版] 3.9 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, P.R. China.

通讯作者：

通讯机构： [1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, P.R. China.

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