Purpose: To investigate the effect of application of perioperative quality nursing based on Orem's self -care theory, in combination with apatinib in patients who underwent cholangiocarcinoma resection.Methods: Ninety patients who underwent cholangiocarcinoma resection in The Fourth Hospital of Hebei Medical University from Feb. 2019 to Feb. 2020 were assigned to control group (CG) and study group (SG) based on their order of admission, with 45 patients in each group. Conventional nursing in combination with conventional treatment was applied to CG, while perioperative quality nursing based on Orem's self-care theory was used in combination with apatinib therapy in SG patients. Comparison was made between CG and SG regarding clinical efficacy, self-care ability and quality of life (QoL, based on QLQ-C30 score).Results: Disease control rate (DCR) and Barthel index (BI) score were higher in SG than in CG (p < 0.05). After treatment, QoL score was higher in SG than in CG (p < 0.001).Conclusion: Implementation of perioperative quality nursing along with apatinib therapy in patients undergoing cholangiocarcinoma resection improves their QoL and enhances their self-care ability. Thus, this treatment modality has high utility and treatment potential.