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Predictive value of admission CO2 combining power combined with serum sodium for the prognosis in acute Stanford type A aortic dissection patients

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机构： [1]School of Public Health, North China University of Science and Technology, Tangshan 063210, Hebei, People’sRepublic of China [2]Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and VascularBiology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic ofChina [3]Cardiac Surgery Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050017,Hebei, People’s Republic of China

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Acute Stanford type A aortic dissection (ATAAD) with sudden onset and high mortality requiries a standard Bentall operation and a accurate prognosis in common, together with alteration of CO2 combining power (CO2CP) and serum sodium rase concern, hence, we evaluated the prognostic value of CO2CP combined with serum sodium in ATAAD patients. This retrospective study included 183 patients who underwent Bentall operation for ATAAD from 2015 to 2021 in the Fourth Hospital of Hebei Medical University, subsequently followed grouping by the levels of CO2CP and serum sodium. The study endpoint was 30-day all-cause mortality, and the prognostic value of CO2CP combined with serum sodium levels in ATAAD patients were evaluated with multivariate logistic regression method. The postoperative incidence of in-hospital death and adverse events in patients with ATAAD were 18% and 25.7%, respectively. Combination of CO2CP and serum sodium for predicting ATAAD death and adverse events presented a higher predictive value than each single indicator with ROC curve analysis (the AUC of CO2CP combined with serum sodium was 0.786, 95% CI 0.706-0.869, P < 0.001), along with CO2CP < 22.5 mmol/L + serum sodium > 138.5 mmol/L group had the worst prognostic. Multivariate regression analyse showed that CO2CP < 22.5 mmol/L combined with serum sodium > 138.5 mmol/L preferably predicted the prognosis of ATAAD (OR =6.073, 95% CI 2.557-14.425, P < 0.001). Consistently, the cumulative 30-day survival after surgery in ATAAD patients with the low CO2CP and high serum sodium simultaneously was the worst (log-rank P < 0.05). The combination of CO2CP and serum sodium increases the predictive value of prognosis, which is conducive to risk stratification of patients with ATAAD.© 2023. The Author(s).

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出版当年[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2024]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.9 最新[2024版] 4.3 最新五年平均 3.8 出版当年[2023版] 4.3 出版当年五年平均 4.6 出版前一年[2022版] 3.9 出版后一年[2024版]

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第一作者机构： [1]School of Public Health, North China University of Science and Technology, Tangshan 063210, Hebei, People’sRepublic of China

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通讯机构： [1]School of Public Health, North China University of Science and Technology, Tangshan 063210, Hebei, People’sRepublic of China [2]Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and VascularBiology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic ofChina [3]Cardiac Surgery Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050017,Hebei, People’s Republic of China

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