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Characteristics and prognosis of distant metastasis after primary treatment for early-stage extranodal nasal-type natural killer/T-cell lymphoma from the China Lymphoma Collaborative Group database

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收录情况： ◇ ESCI

作者：
Zheng Xuan[1,2] * ; Qu Bao-Lin[3] * ; Liu Xin[1] * ; Zhong Qiu-Zi[4] ; Qian Li-Ting[5] ; Yang Yong[6] ; Hou Xiao-Rong[7] ; Qiao Xue-Ying[8] ; Wang Hua[9] ; Zhu Yuan[10] ; Cao Jian-Zhong[11] ; Wu Jun-Xin[12] ; Wu Tao[13] ; Zhu Su-Yu[14] ; Shi Mei[15] ; Zhang Hui-Lai[16] ; Zhang Xi-Mei[17] ; Su Hang[18] ; Song Yu-Qin[19] ; Zhu Jun[19] ; Zhang Yu-Jing[20] ; Huang Hui-Qiang[21] ; Wang Ying[22] ; Chen Fan[23] ; Yin Lin[23] ; He Xia[24] ; Zhang Li-Ling[25] ; Li Ye-Xiong[1,*1] ; Qi Shu-Nan[1,*1] ;
机构： [1]Department of RadiationOncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and Peking UnionMedical College, Beijing, China [2]Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China [3]Department of RadiationOncology, The General Hospital of Chinese People’s Liberation Army, Beijing, China [4]Department of RadiationOncology, Beijing Hospital, National GeriatricMedical Center, Beijing, China [5]Department of RadiationOncology, The Affiliated Provincial Hospital of Anhui Medical University, Hefei, China [6]Department of RadiationOncology, Fujian Medical University Union Hospital, Fuzhou, China [7]Department of RadiationOncology, Peking UnionMedical College Hospital, Chinese Academy ofMedical Sciences (CAMS) and Peking UnionMedical College (PUMC), Beijing, China [8]Department of RadiationOncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [9]Department of Medical Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, China [10]Department of RadiationOncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang Key Laboratory of RadiationOncology, Zhejiang, China [11]Department of RadiationOncology, Shanxi Cancer Hospital and the Affiliated Cancer Hospital of ShanxiMedical University, Taiyuan, China [12]Department of RadiationOncology, Fujian Provincial Cancer Hospital, Fuzhou, China [13]Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guiyang, China [14]Department of RadiationOncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, China [15]Department of RadiationOncology, Xijing Hospital of Fourth MilitaryMedical University, Xi’an, China [16]Department of Lymphoma, TianjinMedical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China [17]Department of RadiationOncology, TianjinMedical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China [18]Department of Lymphoma, The Fifth Medical Center of PLA General Hospital, Beijing, China [19]Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China [20]Department of RadiationOncology, Sun Yat-sen University Cancer Center [21]State Key Laboratory ofOncology in South China [22]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [23]Department of Medical Oncology, Sun Yat-sen University Cancer Center [24]State Key Laboratory of Oncology in South China [25]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [26]Department of RadiationOncology, Chongqing University Cancer Hospital and Chongqing Cancer Hospital, Chongqing, China [27]Department of RadiationOncology, Affiliated Hospital of Qinghai University, Qinghai, China [28]Department of RadiationOncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China [29]Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1002/jha2.613
ISSN：

摘要：
This study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early-stage extranodal nasal-type natural killer (NK)/T-cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrospectively reviewed. The cumulative incidence of DM was assessed using Fine and Gray's competing risk analysis. The correlation between DM sites was evaluated using phi coefficients, while DM sites were classified using hierarchical clustering. Regression analysis was used to assess the linear correlation between DM-free survival (DMFS) and overall survival (OS). The 5-year cumulative DM rate was 26.2%, with the highest annual hazard rate being in the first year (14.9%). The most frequent DM sites were the skin and soft tissues (SSTs, 32.4%) and distant lymph nodes (LNs, 31.3%). DM sites were categorized into four subgroups of distinct prognosis - distant LN, SST, extracutaneous site, and lymphoma-associated hemophagocytic lymphohistiocytosis. SST or distant LN, solitary metastasis, and late-onset DM demonstrated a relatively favorable prognosis. Contemporary chemotherapy significantly decreased DM rates and improved DMFS. Decreased DM rates were further associated with increased OS probabilities. Our findings improve the understanding of the variable clinical behaviors of early-stage ENKTCL based on four distinct DM sites and thus provide guidance for future therapeutic decisions, metastatic surveillance, and translational trial design.© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.

基金：
National Key Research and Development of China, Grant/Award Number: 2020AAA0109504; National Natural Science Foundation of China, Grant/Award Number: 81970185; Beijing Hope Run Special Fund of Cancer Foundation of China, Grant/Award Number: LC2020B07; The training project of “National Tutor System for Young Health Talents in Suzhou”
语种：
外文
WOS：
PubmedID：
第一作者：
第一作者机构： [1]Department of RadiationOncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and Peking UnionMedical College, Beijing, China [2]Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of RadiationOncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy ofMedical Sciences and Peking UnionMedical College, Beijing, China [*1]Department of RadiationOncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing 100021, China.
推荐引用方式(GB/T 7714)：
Zheng Xuan,Qu Bao-Lin,Liu Xin,et al.Characteristics and prognosis of distant metastasis after primary treatment for early-stage extranodal nasal-type natural killer/T-cell lymphoma from the China Lymphoma Collaborative Group database[J].EJHAEM.2023,4(1):78-89.doi:10.1002/jha2.613.
APA：
Zheng Xuan,Qu Bao-Lin,Liu Xin,Zhong Qiu-Zi,Qian Li-Ting...&Qi Shu-Nan.(2023).Characteristics and prognosis of distant metastasis after primary treatment for early-stage extranodal nasal-type natural killer/T-cell lymphoma from the China Lymphoma Collaborative Group database.EJHAEM,4,(1)
MLA：
Zheng Xuan,et al."Characteristics and prognosis of distant metastasis after primary treatment for early-stage extranodal nasal-type natural killer/T-cell lymphoma from the China Lymphoma Collaborative Group database".EJHAEM 4..1(2023):78-89

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