详情页 - 河北医科大学第四医院机构库

当前位置：首页 > 详情页

Therapeutic effects of atorvastatin on doxorubicin-induced hepatotoxicity in rats via antioxidative damage, anti-inflammatory, and anti-lipotoxicity

10| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Otorhinolarynology-Head and Neck Sergery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [2]The Key Laboratory of Pharmacology and Toxicology for New Drugs, Department of Pharmacology, Hebei Medical University, Shijiazhuang, China. [3]The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China. [4]Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [5]Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

出处：

DOI：

ISSN：

摘要：

Doxorubicin (DOX), is a high efficiency anthracycline antitumor drug. However, the clinical application of DOX is limited mainly by dose-related adverse drug reactions. Currently, the therapeutic effects of Atorvastatin (ATO) on DOX-induced hepatotoxicity were studied in vivo. The results indicated that DOX impaired hepatic function, as measured by an increased levels of liver weight index and serum concentrations of aspartate transaminase and alanine transaminase, as well as alteration of hepatic histology. In addition, DOX increased the serum levles of triglyceride (TG) and nonestesterified fatty acid. ATO prevented these changes. Mechanical analysis revealed that ATO restored the changes of malondialdehyde, reactive oxygen radical species, glutathione peroxidase and manganese superoxide dismutase. Additionally, ATO inhibited the increased expression levels of nuclear factor-kappa B and interleukin 1β, hence suppressing inflammation. Meanwhile, ATO inhibited cell apoptosis by dramatically decreasing the Bax/Bcl-2 ratio. In addition, ATO mitigated the lipidtoxicity by inhibiting the adipolysis of TG and accelerating hepatic lipid metabolism. Taken together, the results suggest ATO has therapeutic effect on DOX-induced hepatotoxicity via inhibition of oxidative damage, inflammatory and apoptosis. In addition, ATO attenuates DOX-induced hyperlipidemia via modulation of lipid metabolism.© 2023 Wiley Periodicals LLC.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区毒理学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区毒理学

JCR分区：

出版当年[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 TOXICOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 TOXICOLOGY

影响因子： 3.2 最新[2023版] 3.4 最新五年平均 3.2 出版当年[2023版] 3.4 出版当年五年平均 3.6 出版前一年[2022版]

第一作者：

第一作者机构： [1]Department of Otorhinolarynology-Head and Neck Sergery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

共同第一作者：

通讯作者：

通讯机构： [2]The Key Laboratory of Pharmacology and Toxicology for New Drugs, Department of Pharmacology, Hebei Medical University, Shijiazhuang, China. [3]The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China. [*1]The Key Laboratory of Pharmacology and Toxicology for New Drugs, Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：