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Effect of one-lung ventilation on the correlation between left and right cerebral saturation

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机构： [1]Department of Anesthesiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China [2]Department of Anesthesiology, Peking University First Hospital, Xishiku Street No.8, Beijing 100034, China [3]Department of Anesthesiology, Tangshan Gongren Hospital, Hebei, China

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To investigate if the correlation between left and right cerebral tissue oxygen saturation (SctO2) was affected by one-lung ventilation (OLV) in patients undergoing lung cancer surgery.Patients who underwent surgery for lung cancer were enrolled. Left and right SctO2 were collected during anesthesia. The primary outcome was the correlation between left and right SctO2 at 30 min after OLV which was analysed by Pearson correlation and linear regression model. Secondary outcomes included the trend of left-right SctO2 change over the first 30 min after OLV, correlation of left-right SctO2 during OLV for each patient; maximal difference between left-right SctO2 and its relationship with postoperative delirium.Left-right SctO2 was moderately correlated at baseline (r = 0.690, P < 0.001) and poorly correlated at 30 min after OLV (r = 0.383, P < 0.001) in the Pearson correlation analysis. Linear regression analysis showed a poor correlation between left and right SctO2 at 30 min after OLV (r = 0.323, P < 0.001) after adjusting for confounders. The linear mixed model showed a change in left-right SctO2 over the first 30 min after OLV that was statistically significant (coefficient, -0.042; 95% CI, -0.070--0.014; P = 0.004). For the left-right SctO2 correlation during OLV in each patient, 62.9% (78/124) patients showed a strong correlation, 19.4% (24/124) a medium correlation, and the rest a poor correlation. The maximal difference between the left and right SctO2 was 13.5 (9.0, 20.0). Multivariate analysis showed that it was not associated with delirium (odds ratio [OR], 1.023; 95% CI, 0.963-1.087; P = 0.463).The correlation between left and right SctO2 was affected by one-lung ventilation in patients undergoing lung cancer surgery. This result indicates the requirement of bilateral SctO2 monitoring to reflect brain oxygenation.This study was a secondary analysis of a cohort study approved by the Clinical Research Review Board of Peking University First Hospital (#2017-1378) and was registered in the Chinese Clinical Trial Registry on 10/09/2017 ( http://www.chictr.org.cn , ChiCTR-ROC-17012627).© 2023. The Author(s).

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中科院分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区麻醉学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区麻醉学

JCR分区：

出版当年[2023]版：

Q2 ANESTHESIOLOGY

最新[2024]版：

Q2 ANESTHESIOLOGY

影响因子： 2.6 最新[2024版] 2.6 最新五年平均 2.3 出版当年[2023版] 2.6 出版当年五年平均 2.2 出版前一年[2022版] 2.6 出版后一年[2024版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China [2]Department of Anesthesiology, Peking University First Hospital, Xishiku Street No.8, Beijing 100034, China [3]Department of Anesthesiology, Tangshan Gongren Hospital, Hebei, China

通讯作者：

通讯机构： [1]Department of Anesthesiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China

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