GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway
机构：[1]Diagnostic and Therapeutic Center for Breast Disease, The Fourth Hospital of Hebei Medical University.河北医科大学第四医院[2]The Second Department of Thyroid and Breast Surgery, Cangzhou Central Hospital.[3]Key Laboratory of Molecular Medicine of Breast Cancer in Hebei.
Triple-negative breast cancer (TNBC) puts a great threat to women's health. GLIS family zinc finger 3 (GLIS3) belongs to the GLI transcription factor family and acts as a critical factor in cancer progression. Nevertheless, the part of GLIS3 played in TNBC is not known. Immunohistochemical (IHC) staining analysis displayed that GLIS3 was highly expressed in TNBC tissues. The effect of GLIS3 on the malignant phenotype of TNBC was tested in two different cell lines according to GLIS3 regulation. Upregulation of GLIS3 promoted the proliferation, migration, and invasion of TNBC cell lines, whereas the knockdown of GLIS3 suppressed these tumor activities. Inhibition of GLIS3 induced TNBC cell apoptosis. Furthermore, study as immunofluorescence and electrophoretic mobility shift assay confirmed that the nuclear factor-κB (NF-κB) signaling pathway activated by GLIS3 played an important role in TNBC cells' malignant phenotype. In conclusion, the present work demonstrated that GLIS3 acts as a crucial element in TNBC progression via activating the NF-κB signaling pathway. Accordingly, above mentioned findings indicated that modulation of GLIS3 expression is a potential tactic to interfere with the progression of TNBC.
基金：
This work was supported by the Natural
Science Foundation of Hebei Province (No. H2020206199).
第一作者机构：[1]Diagnostic and Therapeutic Center for Breast Disease, The Fourth Hospital of Hebei Medical University.[2]The Second Department of Thyroid and Breast Surgery, Cangzhou Central Hospital.
通讯作者：
通讯机构：[1]Diagnostic and Therapeutic Center for Breast Disease, The Fourth Hospital of Hebei Medical University.[3]Key Laboratory of Molecular Medicine of Breast Cancer in Hebei.
推荐引用方式(GB/T 7714)：
Li Chenhao,Geng Cuizhi.GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway[J].BIOLOGICAL & PHARMACEUTICAL BULLETIN.2023,46(2):209-218.doi:10.1248/bpb.b22-00595.
APA：
Li Chenhao&Geng Cuizhi.(2023).GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway.BIOLOGICAL & PHARMACEUTICAL BULLETIN,46,(2)
MLA：
Li Chenhao,et al."GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway".BIOLOGICAL & PHARMACEUTICAL BULLETIN 46..2(2023):209-218
