Exosomes Secreted from Mesenchymal Stem Cells Carry miR-486-5p to Inhibit Cell Proliferation and the Epithelial-Mesenchymal Transition Process to Treat Human Lung Cancer by Down-Regulating MIER3
Exosomes are nano-vesicles that can shuttle active cargoes. Mesenchymal stem cells play a complex function in tumour progression. We investigated the effect of miR-486-5p, an exosome of human bone marrow-derived MSCs on lung cancer. We found that miR-486-5p, carried in mesenchymal stem cells and mesenchymal stem cell-derived exosomes, regulates MIER3 expression by binding to its 3' UTR, thereby inhibiting the epithelial-mesenchymal transition process of A549 cells. In vivo, we demonstrated that exosome treatment reduced the area of tumour necrosis, increased the expression of miR-486-5p and inhibited the epithelial-mesenchymal transition process in mice. In conclusion, mesenchymal stem cell-derived exosomal miR-486-5p directly and negatively targets MIER3 to inhibit lung cancer.
基金：
Key Program of Medical Science Research of Hebei Province [20221350]
第一作者机构：[1]Hebei Med Univ, Dept Resp Med, Hosp 4, Shijiazhuang 050000, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Resp Med, Hosp 4, Shijiazhuang 050000, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Peng Jingcui,Li Sa,Li Bin,et al.Exosomes Secreted from Mesenchymal Stem Cells Carry miR-486-5p to Inhibit Cell Proliferation and the Epithelial-Mesenchymal Transition Process to Treat Human Lung Cancer by Down-Regulating MIER3[J].JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.2022,18(10):2364-2376.doi:10.1166/jbn.2022.3444.
APA：
Peng, Jingcui,Li, Sa,Li, Bin,Hu, Wenxia&Ding, Cuimin.(2022).Exosomes Secreted from Mesenchymal Stem Cells Carry miR-486-5p to Inhibit Cell Proliferation and the Epithelial-Mesenchymal Transition Process to Treat Human Lung Cancer by Down-Regulating MIER3.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,18,(10)
MLA：
Peng, Jingcui,et al."Exosomes Secreted from Mesenchymal Stem Cells Carry miR-486-5p to Inhibit Cell Proliferation and the Epithelial-Mesenchymal Transition Process to Treat Human Lung Cancer by Down-Regulating MIER3".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 18..10(2022):2364-2376
