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Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation

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收录情况： ◇ SCIE

作者：
Li Congxin[1] * ; Wu Wenting[2] ; Xing Jiahui[2] ; Yan Wei[1] ; Zhang Jiali[2] ; Sun Jinglei[2] ; Zhang Zhihan[3] ; Qiu Suhua[2] ; Xu Yanfang[2] ; Wang Xianying[1,*1] ;
机构： [1]Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China [2]Department of Pharmacology, Hebei Medical University, The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, 050017, China [3]Department of Nutrition, The Fourth Hospital of Hebei Medical University,Shijiazhuang, 050010, China
出处：
DOI： 10.1016/j.fct.2023.113743
ISSN：

关键词： Berberine Sunitinib Cardiac contractile dysfunction Phosphoinositide 3-kinase Serum and glucocorticoid-regulated kinase 1 Human-induced pluripotent stem cell-derived cardiomyocyte

摘要：
Sunitinib (SNT)-induced cardiotoxicity is associated with abnormal calcium regulation caused by phosphoinositide 3 kinase inhibition in the heart. Berberine (BBR) is a natural compound that exhibits cardioprotective effects and regulates calcium homeostasis. We hypothesized that BBR ameliorates SNT-induced cardiotoxicity by normalizing the calcium regulation disorder via serum and glucocorticoid-regulated kinase 1 (SGK1) activation. Mice, neonatal rat cardiomyocytes (NRVMs), and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were used to study the effects of BBR-mediated SGK1 activity on the calcium regulation disorder caused by SNT as well as the underlying mechanism. BBR offered prevention against SNT-induced cardiac systolic dysfunction, QT interval prolongation, and histopathological changes in mice. After the oral administration of SNT, the Ca2+ transient and contraction of cardiomyocytes was significantly inhibited, whereas BBR exhibited an antagonistic effect. In NRVMs, BBR was significantly preventive against the SNT-induced reduction of calcium transient amplitude, prolongation of calcium transient recovery, and decrease in SERCA2a protein expression; however, SGK1 inhibitors resisted the preventive effects of BBR. In hiPSC-CMs, BBR pretreatment significantly prevented SNT from inhibiting the contraction, whereas coincubation with SGK1 inhibitors antagonized the effects of BBR. These findings indicate that BBR attenuates SNT-induced cardiac dysfunction by normalizing the calcium regulation disorder via SGK1 activation.Copyright © 2023. Published by Elsevier Ltd.

基金：
National Natural Science Foundation of China (grant number 82003878), the Natural Science Foundation of Hebei Province (grant number H2021206026, H2020206554), the Research Foundation of Education Bureau of Hebei Province (grant number BJ2021053), the Clinical Medicine Innovation Research Team Support Project of Hebei Medical University (grant number 2022LCTDB28), and the Hospital Pharmacy Project of Hebei Pharmaceutical Association (grant number 2020-Hbsyxhms0018).
语种：
外文
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中科院分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 食品科技 3 区 毒理学
最新[2025]版：
大类 | 4 区 医学
小类 | 3 区 食品科技 3 区 毒理学
JCR分区：
出版当年[2023]版：
Q1 TOXICOLOGY Q2 FOOD SCIENCE & TECHNOLOGY
最新[2023]版：
Q1 TOXICOLOGY Q2 FOOD SCIENCE & TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China
通讯作者：
通讯机构： [1]Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China [*1]Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
推荐引用方式(GB/T 7714)：
Li Congxin,Wu Wenting,Xing Jiahui,et al.Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation[J].FOOD AND CHEMICAL TOXICOLOGY.2023,175:doi:10.1016/j.fct.2023.113743.
APA：
Li Congxin,Wu Wenting,Xing Jiahui,Yan Wei,Zhang Jiali...&Wang Xianying.(2023).Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation.FOOD AND CHEMICAL TOXICOLOGY,175,
MLA：
Li Congxin,et al."Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation".FOOD AND CHEMICAL TOXICOLOGY 175.(2023)

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