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Evidence of cure for extranodal nasal-type natural killer/T-cell lymphoma with current treatment: an analysis of the CLCG database

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机构: [1]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021. [2]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei. [3]The General Hospital of Chinese People's Liberation Army, Beijing. [4]Beijing Hospital, National Geriatric Medical Center, Beijing. [5]The Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui. [6]Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P. R. China. [7]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing. [8]The Fourth Hospital of Hebei Medical University, Shijiazhuang. [9]Second Affiliated Hospital of Nanchang University, Nanchang. [10]Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Zhejiang. [11]Shanxi Cancer Hospital and the Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan, Shanxi. [12]Fujian Provincial Cancer Hospital, Fuzhou, Fujian. [13]Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guiyang, Guizhou. [14]Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan. [15]Xijing Hospital of Fourth Military Medical University, Xi'an. [16]Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin. [17]The Fifth Medical Center of PLA General Hospital, Beijing. [18]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing. [19]Sun Yat-sen University Cancer Center [20]State Key Laboratory of Oncology in South China [21]Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong. [20]Chongqing University Cancer Hospital and Chongqing Cancer Hospital, Chongqing. [21]Affiliated Hospital of Qinghai University, Qinghai, P. R. China. [22]Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, Jiangsu. [23]Department of Radiation Oncology, the Second Affiliated Hospital of Soochow University, Suzhou.
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Survival from extranodal nasal-type NK/T-cell lymphoma (ENKTCL) has substantially improved over the last decade. However, there is little consensus as to whether a population of patients with ENKTCL can be considered "cured" of the disease. We aimed to evaluate the statistical "cure" of ENKTCL in the modern treatment era. This retrospective multicentric study reviewed the clinical data of 1955 patients with ENKTCL treated with non-anthracycline-based chemotherapy and/or radiotherapy between 2008 and 2016 in China Lymphoma Collaborative Group multicenter database. A non-mixture cure model with incorporation of background mortality was fitted to estimate cure fractions, median survival times and cure time points. The relative survival curves attained plateau for the entire cohort and most subsets, indicating that the notion of cure was robust. The overall cure fraction was 71.9%. Median survival was 1.1 years in uncured patients. The cure time was 4.5 years, indicating that beyond this time, mortality in ENKTCL patients was statistically equivalent to that in the general population. Cure probability was associated with B symptoms, stage, performance status, lactate dehydrogenase, primary tumor invasion, and primary upper aerodigestive tract site. Elderly patients (>60 years) had similar cure fraction to that of younger patients. Five-year overall survival rate correlated well with the cure fraction across risk-stratified groups. Thus, statistical cure is possible in ENKTCL patients receiving current treatment strategies. Overall probability of cure is favorable, though it is affected by presence of risk factors. These findings have a high potential impact on clinical practice and patients' perspective.

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出版当年[2023]版:
大类 | 3 区 文学
小类 | 2 区 罗曼语系文学
最新[2025]版:
大类 | 4 区 文学
小类 | 3 区 罗曼语系文学

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021.
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通讯机构: [1]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021. [*1]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [*2]State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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