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Real-world data indicated that neoadjuvant chemotherapy alone was associated with a higher risk of tumor recurrence in high‑risk breast cancer subgroup patients

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收录情况： ◇ SCIE

作者：
Li Zhensheng[1,*1] * ; Li Yue[1] ; Liu Yunjiang[2,*2] ; Shang Yuguang[1] ; Zhou Yarong[2] ; Ji Xiaohui[3] ; Han Huina[1] ; Du Kaiye[1] ; Zhang Jun[1] ;
机构： [1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China. [2]Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China. [3]Department of Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China.
出处：
DOI： 10.3892/ol.2023.13779
ISSN：

关键词： breast cancer disease‑free survival neoadjuvant chemotherapy adjuvant chemotherapy real‑world data

摘要：
Numerous clinical trials have reported equal effects of tumor control between neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC) in patients with breast cancer (BC). However, this conclusion has not been verified in practice. The present retrospective study evaluated if there were different risk profiles for NAC, AC and their combinative modes on disease-free survival (DFS) in patients with BC using real-world data. All women with primary unilateral Stage I-III BC and first recurrence in 2008-2018 at The Fourth Hospital of Hebei Medical University were retrospectively identified for enrollment. The four modes of chemotherapy administered for primary BC were classified as 'None', 'NAC only', 'NAC+AC' and 'AC only'. One multivariate Cox model was used to estimate the adjusted Hazard Ratio (HR) and P-value. Covariates included age, Easter Cooperative Oncology Group grade, T stage, N stage, pathology, grade, lymphovascular invasion (LVI), BC subtype, number of chemotherapy cycles and other therapies. Amongst 637 patients, who had a mean age of 48.2 years at BC diagnosis and 50.9 years at recurrence, the median DFS by the 'None' (n=27), 'NAC only' (n=47), 'NAC+AC' (n=118) and 'AC only' (n=445) modes were 31.4, 16.6, 22.6 and 28.4 months (P<0.001), respectively. Compared with the 'AC only', adjusted HR (P-value) of the 'None', 'NAC only' and 'NAC+AC' modes on tumor recurrence were 1.182 (0.551), 1.481 (0.037) and 1.102 (0.523), respectively. The adjusted HR of 'NAC only' vs. 'AC only' modes were 1.448 (P=0.157) for locoregional recurrence and 2.675 (P=0.003) for distant recurrence. Stratified analyses further indicated that the 'NAC only' mode was associated with a higher recurrence risk in T3-4, N2-3, LVI-positive, or HER2-negative subgroup patients. In conclusion, NAC alone was associated with a higher risk of tumor recurrence in high-risk BC subgroup patients in real-world data. Patient selection of chemotherapy mode was involved in practice but could not fully explain this finding. The 'inadequate' NAC was highly likely to have accounted for this observation.Copyright: © Li et al.

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中科院分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2023]版：
Q3 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China. [*1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, 169 Tianshan Street, Shijiazhuang, Hebei 050035, P.R. China
通讯作者：
通讯机构： [1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China. [2]Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China. [*1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, 169 Tianshan Street, Shijiazhuang, Hebei 050035, P.R. China [*2]Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, 169 Tianshan Street, Shijiazhuang, Hebei 050035, P.R. China
推荐引用方式(GB/T 7714)：
Li Zhensheng,Li Yue,Liu Yunjiang,et al.Real-world data indicated that neoadjuvant chemotherapy alone was associated with a higher risk of tumor recurrence in high&#x2011;risk breast cancer subgroup patients[J].ONCOLOGY LETTERS.2023,25(5):doi:10.3892/ol.2023.13779.
APA：
Li Zhensheng,Li Yue,Liu Yunjiang,Shang Yuguang,Zhou Yarong...&Zhang Jun.(2023).Real-world data indicated that neoadjuvant chemotherapy alone was associated with a higher risk of tumor recurrence in high&#x2011;risk breast cancer subgroup patients.ONCOLOGY LETTERS,25,(5)
MLA：
Li Zhensheng,et al."Real-world data indicated that neoadjuvant chemotherapy alone was associated with a higher risk of tumor recurrence in high&#x2011;risk breast cancer subgroup patients".ONCOLOGY LETTERS 25..5(2023)

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