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Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients

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机构： [1]Department of Hematology, Key Laboratory of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China [2]Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China [3]Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China [4]College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China

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关键词： Leukemia AML ROBO3 Migration Proliferation Adhesion SLIT-ROBO family KG-1

摘要：

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, which is the most common and severe acute leukemia in adults. Its occurrence, development and prognosis are affected by many factors, and more research is still needed to further guide its treatment. Here, we found that roundabout3 (ROBO3) was associated with poor prognosis in AML through bioinformatics analysis. We then found that overexpression of ROBO3 promoted AML cell proliferation, adhesion and migration while knockdown of ROBO3 had opposite effects. We subsequently found that ROBO3 regulated CD34 expression in AML cells, and this regulatory effect may be achieved through the Hippo-YAP pathway. The inhibitors of this pathway, K-975 and verteporfin, showed an inhibitory effect on AML cells with high ROBO3 expression. ROBO3 was also found to be significantly increased in bone marrow samples from AML patients. Our research indicates that ROBO3 plays an important role in the development of AML, which suggests that ROBO3 can be a prognostic biomarker and potential therapeutic target for AML.Copyright © 2023. Published by Elsevier Inc.

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中科院分区：

出版当年[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

JCR分区：

出版当年[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

最新[2024]版：

Q3 BIOPHYSICS Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 2.2 最新[2024版] 2.5 最新五年平均 2.5 出版当年[2023版] 2.7 出版当年五年平均 3.1 出版前一年[2022版] 2.2 出版后一年[2024版]

第一作者：

第一作者机构： [1]Department of Hematology, Key Laboratory of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China [2]Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

通讯作者：

通讯机构： [1]Department of Hematology, Key Laboratory of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China [*1]Department of Hematology, Key Laboratory of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China.

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Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients

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