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Circ_0001953 contribute to retinal vascular endothelial cell injury induced by high glucose through regulating miR-186

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机构： [1]Fourth Hosp Hebei Med Univ, Dept Ophthalmol, Shijiazhuang 050000, Hebei, Peoples R China [2]Shijiazhuang peoples Hosp, Dept Ophthalmol, Shijiazhuang 050003, Hebei, Peoples R China

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关键词： circ_0001953 miR-186 HRVECs inflammation oxidative stress apoptosis

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Purpose: To investigate the effects of circ_0001953/miR-186 on human retinal vascular endothelial cell (HRVEC) injury evoked by high glucose. Methods: A cell model (HG group) was established using high glucose-treated HRVECs, while untreated HRVECs were used as the control group (Con group). The levels of endothelin-1 (ET-1), ICAM-1 and IL-6 were evaluated by ELISA and the content of malondialdehyde (MDA) and superoxide dismutase (SOD) in HRVECs were determined. Apoptosis rate was tested adopting flow cytometry. The interrelationship between circ_0001953 and miR-186 was assessed using dual luciferase reporter assay. Measurement of Bax and Bcl-2 was implemented via western blot. Results: In HG group, circ_0001953 increased while miR-186 was downregulated, ET-1, IL-6, ICAM-1, and apoptosis rate increased and accompanied with up-regulated Bax content and declined Bcl-2 protein level. Furthermore, the content of MDA increased and SOD decreased. MiR-186 was a target of circ_0001953. Conclusion: Inhibition of circ_0001953 can repress inflammation, oxidative stress and apoptosis in HRVECs by up-regulating the expression of miR-186.

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中科院分区：

出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区药学

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出版当年[2023]版：

Q4 PHARMACOLOGY & PHARMACY

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影响因子： 0 最新[2024版] 0 最新五年平均 0.6 出版当年[2023版] 0.6 出版当年五年平均 0.6 出版前一年[2022版]

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第一作者机构： [1]Fourth Hosp Hebei Med Univ, Dept Ophthalmol, Shijiazhuang 050000, Hebei, Peoples R China

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通讯机构： [1]Fourth Hosp Hebei Med Univ, Dept Ophthalmol, Shijiazhuang 050000, Hebei, Peoples R China

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