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Which factors predict parametrial involvement in stage IB cervical cancer? A Chinese multicentre study

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收录情况： ◇ SCIE

作者：
Liang Cong[1] * ; Jiang Haixia[1,2] * ; Sun Lixin[3] * ; Kang Shan[4] * ; Cui Zhumei[5] ; Wang Li[6] ; Zhao Weidong[7] ; Bin Xiaonong[8] ; Lang Jinghe[9] ; Liu Ping[1,*1] ; Chen Chunlin[1,*1] ;
机构： [1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China [2]Department of Gynecology, Chengdu Second People's Hospital, Chengdu, China [3]Department of Gynecologic Oncology, Shanxi Provincial Cancer Hospital, Taiyuan, China [4]Department of Gynecology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China [5]Department of Gynecology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, China [6]Department of Gynecologic Oncology, Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou, China [7]Department of Gynecology and Oncology, Anhui Provincial Cancer Hospital, Hefei, China [8]Department of Epidemiology, College of Public Health, Guangzhou Medical University, Guangzhou, China [9]Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China
出处：
DOI： 10.1016/j.ejso.2023.05.011
ISSN：

关键词： Cervical cancer Q-M type B radical Hysterectomy Parametrial involvement

摘要：
To explore the clinicopathological risk factors influencing parametrial involvement (PI) in stage IB cervical cancer patients and compare the oncological outcomes between Q-M type B radical hysterectomy (RH) group and Q-M type C RH group.Univariate and multivariate analyses were performed to explore the clinicopathological factors related to PI. Overall survival (OS) and disease-free survival (DFS) in patients with stage IB cervical cancer who underwent Q-M type B or Q-M type C RH under different circumstances of PI were also compared before and after propensity score matching (1:1 matching).A total of 6358 patients were enrolled in this study. Depth of stromal invasion>1/2 (HR: 3.139, 95% CI: 1.550-6.360; P = 0.001), vaginal margin (+) (HR: 4.271, 95% CI: 1.368-13.156; P = 0.011), lymphovascular space invasion (LVSI) (+) (HR: 2.238, 95% CI: 1.353-3.701; P = 0.002) and lymph node metastases (HR: 5.173, 95% CI: 3.091-8.658; P < 0.001) were associated with PI. Among the 6273 patients with negative PI, those in the Q-M type B RH group had a higher 5-year OS and DFS than those in the Q-M type C RH group before and after 1:1 matching. Among the 85 patients with positive PI, Q-M type C RH showed no survival benefits before and after 1:1 matching.Stage IB cervical cancer patients with no lymph node metastasis, LVSI(-) and depth of stromal invasion ≤1/2 may be considered for Q-M type B radical hysterectomy.Copyright © 2023. Published by Elsevier Ltd.

基金：
National Science and Technology Support Program of China (2014BAI05B03), the Natural Science Fund of Guangdong Province (2015A030311024), and the Science and Technology Plan of Guangzhou (158100075).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
JCR分区：
出版当年[2023]版：
Q1 SURGERY Q2 ONCOLOGY
最新[2023]版：
Q1 SURGERY Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China [*1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue, Guangzhou, 510515, China.
推荐引用方式(GB/T 7714)：
Liang Cong,Jiang Haixia,Sun Lixin,et al.Which factors predict parametrial involvement in stage IB cervical cancer? A Chinese multicentre study[J].EJSO.2023,49(9):doi:10.1016/j.ejso.2023.05.011.
APA：
Liang Cong,Jiang Haixia,Sun Lixin,Kang Shan,Cui Zhumei...&Chen Chunlin.(2023).Which factors predict parametrial involvement in stage IB cervical cancer? A Chinese multicentre study.EJSO,49,(9)
MLA：
Liang Cong,et al."Which factors predict parametrial involvement in stage IB cervical cancer? A Chinese multicentre study".EJSO 49..9(2023)

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