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Advances and Challenges for GWAS Analysis in Cardiac Diseases: A Focus on Coronary Artery Disease (CAD)

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收录情况： ◇ SCIE

作者：

机构： [1]Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Beibei, Chongqing 400715, China [2]Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing 400715, China [3]Women Medical and Dental College, Khyber Medical University, Peshawar, KPK, Pakistan [4]Centre for Cell Factories and Biopolymers (CCFB), Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia [5]Department of Physical Sport Science, College of Education, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. [6]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China [7]Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, Pakistan [8]Department of Pharmacy, Kohat University of Science and Technology, 26000, KPK, Pakistan [9]Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

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关键词： Genome-wide association studies coronary artery disease multi-omics functional genomics

摘要：

The achievement of genome-wide association studies (GWAS) has rapidly progressed our understanding of the etiology of coronary artery disease (CAD). It unlocks new strategies to strengthen the stalling of CAD drug development. In this review, we highlighted the recent drawbacks, mainly pointing out those involved in identifying causal genes and interpreting the connections between disease pathology and risk variants. We also benchmark the novel insights into the biological mechanism behind the disease primarily based on outcomes of GWAS. Furthermore, we also shed light on the successful discovery of novel treatment targets by introducing various layers of "omics" data and applying systems genetics strategies. Lastly, we discuss in-depth the significance of precision medicine that is helpful to improve through GWAS analysis in cardiovascular research.Copyright © 2023. Published by Elsevier Inc.

基金：

基金编号： cstc2021ycjhbgzxm0033 to K.L.

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中科院分区：

出版当年[2023]版中科院分区表Review为是的期刊

：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

最新[2025]版

：

大类 | 3 区医学

小类 | 3 区心脏和心血管系统

JCR分区：

出版当年[2023]版：

Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

最新[2024]版：

Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

影响因子： 3.3 最新[2024版] 3.4 最新五年平均 3 出版当年[2023版] 3.5 出版当年五年平均 4.2 出版前一年[2022版] 3.3 出版后一年[2024版]

第一作者：

第一作者机构： [1]Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Beibei, Chongqing 400715, China [2]Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing 400715, China [3]Women Medical and Dental College, Khyber Medical University, Peshawar, KPK, Pakistan

共同第一作者：

通讯作者：

通讯机构： [1]Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Beibei, Chongqing 400715, China [2]Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing 400715, China

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Advances and Challenges for GWAS Analysis in Cardiac Diseases: A Focus on Coronary Artery Disease (CAD)

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