6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification
机构：[1]Hebei Med Univ, Hosp 4, Shijiazhuang, Hebei, Peoples R China河北医科大学第四医院[2]Hebei Univ Chinese Med, Sch Pharm, Shijiazhuang, Hebei, Peoples R China[3]Hebei Med Univ, Sch Pharm, Shijiazhuang, Hebei, Peoples R China[4]Hebei Key Lab Integrat Med Liver Kidney Patterns, Shijiazhuang, Hebei, Peoples R China[5]Hebei Univ Chinese Med, Affiliated Hosp, Shijiazhuang, Hebei, Peoples R China[6]Hebei Univ Chinese Med, Sch Basic Med, Shijiazhuang, Hebei, Peoples R China[7]Hebei Univ Chinese Med, Sch Integrat Med, Shijiazhuang, Hebei, Peoples R China
6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacology and animal experiment results respectively indicated that oxidative stress and in-flammatory responses were closely related to ATO-induced liver injury. 6G can alleviate ATO-induced liver injury and oxidative stress. Furthermore, 6G can attenuate the release of pro -inflammatory factors induced by ATO and reduce the expressions of NLRP3, ASC, Caspase-1 and gasdermin-D. The results showed that the activation of NLRP3 inflammatory and its induced pyroptosis play critical roles in liver injury caused by ATO. Furthermore, 6G can suppress the ROS-NLRP3 inflammasome signaling pathway, which may be an effective strategy for the treatment of ATO-induced liver injury.
基金：
Research Foundation of Natural Science of Hebei Province Youth Project [H2021423027]; Medical Science Research of Hebei Province [20221709]; Construction Program of New Research and Development Platform and Institution,Hebei Province Innovation Ability Promotion Plan [20567624H]; Finance Department of Hebei Province [2019061444]
第一作者机构：[1]Hebei Med Univ, Hosp 4, Shijiazhuang, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Hebei Univ Chinese Med, Sch Pharm, Shijiazhuang, Hebei, Peoples R China[4]Hebei Key Lab Integrat Med Liver Kidney Patterns, Shijiazhuang, Hebei, Peoples R China[5]Hebei Univ Chinese Med, Affiliated Hosp, Shijiazhuang, Hebei, Peoples R China[6]Hebei Univ Chinese Med, Sch Basic Med, Shijiazhuang, Hebei, Peoples R China[7]Hebei Univ Chinese Med, Sch Integrat Med, Shijiazhuang, Hebei, Peoples R China[*1]School of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China[*2]Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
推荐引用方式(GB/T 7714)：
Wu Yongchao,Sun Xiaoqi,Li Haoying,et al.6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification[J].JOURNAL OF FUNCTIONAL FOODS.2023,105:doi:10.1016/j.jff.2023.105551.
APA：
Wu, Yongchao,Sun, Xiaoqi,Li, Haoying,Chu, Xi,Xue, Yucong...&Wang, Xiangting.(2023).6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification.JOURNAL OF FUNCTIONAL FOODS,105,
MLA：
Wu, Yongchao,et al."6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification".JOURNAL OF FUNCTIONAL FOODS 105.(2023)
农林科学