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Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

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收录情况： ◇ SCIE

作者：
Xu Xin[1,2,3] * ; Zhang Dan-Dan[1,2,3] * ; Kong Peng[1,2,3] ; Gao Ya-Kun[1,2,3] ; Huang Xiao-Fu[1,2,3] ; Song Yu[1,2,3] ; Zhang Wen-Di[1,2,3] ; Guo Rui-Juan[1,2,3] ; Li Chang-Lin[1,2,3] ; Chen Bo-Wen[4] ; Sun Yue[4] ; Zhao Yong-Bo[4] ; Jia Fang-Yue[1,2,3] ; Wang Xu[1,2,3] ; Zhang Fan[1,2,3] ; Han Mei[1,2,3] ;
机构： [1]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China [2]Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China [3]Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang 050017, China [4]Department of Cardiac Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China
出处：
DOI： 10.1016/j.celrep.2023.112869
ISSN：

摘要：
Vascular smooth muscle cells (VSMCs) can transdifferentiate into macrophage-like cells in the context of sustained inflammatory injury, which drives vascular hyperplasia and atherosclerotic complications. Using single-cell RNA sequencing, we identify that macrophage-like VSMCs are the key cell population in mouse neointimal hyperplasia. Sex-determining region Y (SRY)-related HMG-box gene 10 (Sox10) upregulation is associated with macrophage-like VSMC accumulation and pyroptosis in vitro and in the neointimal hyperplasia of mice. Tumor necrosis factor α (TNF-α)-induced Sox10 lactylation in a phosphorylation-dependent manner by PI3K/AKT signaling drives transcriptional programs of VSMC transdifferentiation, contributing to pyroptosis. The regulator of G protein signaling 5 (RGS5) interacts with AKT and blocks PI3K/AKT signaling and Sox10 phosphorylation at S24. Sox10 silencing mitigates vascular inflammation and forestalls neointimal hyperplasia in RGS5 knockout mice. Collectively, this study shows that Sox10 is a regulator of vascular inflammation and a potential control point in inflammation-related vascular disease.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (91739301 and 91849102 to M.H. and 32171018 to F.Z.), STI 2030-Major Projects (2021ZD0203200-04 to F.Z.), the Key Natural Science Foundation Projects of Hebei Province (H2019206028 to M.H.), and the Natural Science Foundation of Hebei Province (H2022206011 to F.Z. and H2021206006 to P.K.).
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外文
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中科院分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2023]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China [2]Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China [3]Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang 050017, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China [2]Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China [3]Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang 050017, China
推荐引用方式(GB/T 7714)：
Xu Xin,Zhang Dan-Dan,Kong Peng,et al.Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia[J].CELL REPORTS.2023,42(8):doi:10.1016/j.celrep.2023.112869.
APA：
Xu Xin,Zhang Dan-Dan,Kong Peng,Gao Ya-Kun,Huang Xiao-Fu...&Han Mei.(2023).Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia.CELL REPORTS,42,(8)
MLA：
Xu Xin,et al."Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia".CELL REPORTS 42..8(2023)

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