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LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

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收录情况： ◇ SCIE

作者：
Zhang Zaibo[1] * ; Li Yong[1] ; Fan Liqiao[1] ; Wang Bingyu[1] ; Liu Wenbo[1] ; Cui Jiaxiang[1] ; Tan Bibo[1,2] ;
机构： [1]Department of General Surgery, The Fourth Hospital of Hebei Medical University, 12 Health Road, Chang'an District, Shijiazhuang 050011, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, 12 Health Road, Chang'an District, Shijiazhuang 050011, China.
出处：
DOI： 10.1016/j.isci.2023.107673
ISSN：

摘要：
Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1 were observed in GC and demonstrated a significant positive correlation with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297. Further investigations confirmed that both THUMPD3-AS1 and miR-1297 interact with BCAT1. These findings suggest that THUMPD3-AS1 promotes GC invasion and EMT by regulating the miR-1297/BCAT1 pathway, indicating that THUMPD3-AS1 may serve as a biomarker and therapeutic target for GC.© 2023 The Authors.

基金：
This work is supported by grants from the Hebei Provincial Science and Technology Department’s project of introducing foreign intelligence (Project No. 7002011); The 14th Five-Year Plan for Clinical Medicine Innovation Research Team Support Program of Hebei Medical University (Project No. 2022LCTD-A13); Medical Science Research Project of Hebei Provincial Health Care Commission (Project No. 20230123)
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外文
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出版当年[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
JCR分区：
出版当年[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of General Surgery, The Fourth Hospital of Hebei Medical University, 12 Health Road, Chang'an District, Shijiazhuang 050011, China.
通讯作者：
通讯机构： [1]Department of General Surgery, The Fourth Hospital of Hebei Medical University, 12 Health Road, Chang'an District, Shijiazhuang 050011, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, 12 Health Road, Chang'an District, Shijiazhuang 050011, China.
推荐引用方式(GB/T 7714)：
Zhang Zaibo,Li Yong,Fan Liqiao,et al.LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway[J].ISCIENCE.2023,26(9):doi:10.1016/j.isci.2023.107673.
APA：
Zhang Zaibo,Li Yong,Fan Liqiao,Wang Bingyu,Liu Wenbo...&Tan Bibo.(2023).LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway.ISCIENCE,26,(9)
MLA：
Zhang Zaibo,et al."LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway".ISCIENCE 26..9(2023)

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