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Circ_0001861 facilitates trophoblast cell proliferation, migration, invasion and epithelial-mesenchymal transition via the miR-296-5p/forkhead box protein 1 pathway in preeclampsia

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收录情况： ◇ SCIE

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机构： [1]Department of Obstetrics , The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [2]Medical Insurance Office, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： circ_0001861 forkhead box protein 1 miR-296-5p preeclampsia

摘要：

Preeclampsia (PE) is one of the leading causes of maternal mortality and placental trophoblastic disorders. Recent studies reported that circular RNAs (circRNAs) were involved in PE pathogenesis. However, the role of circ_0001861 in PE progression is largely unknown.The RNA expression of circ_0001861, forkhead box protein 1 (FOXP1) and microRNA-296-5p (miR-296-5p) was detected by quantitative real-time polymerase chain reaction (qRT-PCR) assay. Western blot assay was performed to examine the protein levels of FOXP1 and epithelial-mesenchymal transition (EMT) markers. Cell viability, proliferation, migration and invasion were detected by cell counting kit-8, 5-ethynyl-2'-deoxyuridine, and transwell assays. Luciferase reporter assay, RNA pull-down assay, and RNA immunoprecipitation (RIP) assay were conducted to explore the interaction between miR-296-5p and circ_0001861 or FOXP1.Circ_0001861 and FOXP1 were downregulated but miR-296-5p was upregulated in PE placenta. Upregulation of circ_0001861 facilitated trophoblast cell proliferation, migration, invasion and EMT. Mechanistically, circ_0001861 sponged miR-296-5p to elevate FOXP1 expression, thus promoting trophoblast cell progression.The circ_0001861/miR-296-5p/FOXP1 axis plays a critical role in trophoblast cell proliferation, migration, invasion and EMT, which may provide a novel insight into developing potential therapeutic targets for PE.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区外周血管病

最新[2025]版：

大类 | 3 区医学

小类 | 3 区外周血管病

JCR分区：

出版当年[2024]版：

无

最新[2023]版：

Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 3.3 最新[2023版] 4.4 最新五年平均 3.3 出版当年[2024版] 4.4 出版当年五年平均 3.3 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Obstetrics , The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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通讯作者：

通讯机构： [2]Medical Insurance Office, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [*1]Medical Insurance Office, The Fourth Hospital of Hebei Medical University, No. 169, Tianshan Street, Yuhua District, Shijiazhuang City 050000, Hebei Province, China

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