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Mapping spatial heterogeneity in gastric cancer microenvironment

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机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, China

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关键词： Gastric cancer Tumor microenvironment Spatial heterogeneity Tertiary lymphoid structures

摘要：

Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated heterogeneity leads to the difficulty of precisely targeted therapy. The spatially heterogeneous composition plays a crucial role in GC onset, progression, treatment efficacy, and drug resistance. In recent years, the technological advancements in spatial omics has shifted our understanding of the tumor microenvironment (TME) from cancer-centered model to a dynamic and variant whole. In this review, we concentrated on the spatial heterogeneity within the primary lesions and between the primary and metastatic lesions of GC through the TME heterogeneity including the tertiary lymphoid structures (TLSs), the uniquely spatial organization. Meanwhile, the immune phenotype based on spatial distribution was also outlined. Furthermore, we recapitulated the clinical treatment in mediating spatial heterogeneity in GC, hoping to provide a systematic view of how spatial information could be integrated into anti-cancer immunity.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 2 区药学

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出版当年[2024]版：

无

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.9 最新[2023版] 6.8 最新五年平均 6.9 出版当年[2024版] 6.8 出版当年五年平均 6.9 出版前一年[2023版]

第一作者：

第一作者机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

通讯作者：

通讯机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, China

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