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Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis

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收录情况： ◇ SCIE

作者：
Zeng Xinyu[1] * ; Zhang Rui[2] ; Jiang Weizhong[3] ; Li Chengguo[1] ; Yu Minhao[4] ; Liu Weizhen[1] ; Di Maojun[5] ; Wu Hongxue[6] ; Sun Yueming[7] ; Xiong Zhiguo[8] ; Jiang Congqing[9] ; Yu Bin[10] ; Zhou Shengning[11] ; Li Yong[12] ; Liao Xiaofeng[13] ; Xia Lijian[14] ; Zhang Wei[15] ; Lin Guole[16] ; Tao Kaixiong[1] ;
机构： [1]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of colorectal cancer, Liaoning Cancer Hospital & Institute, Shenyang, China. [3]Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China. [4]Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [5]Department of Gastrointestinal Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China. [6]Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, China. [7]Department of Colorectal Surgery, Jiangsu Province Hospital, Nanjing medical University. Nanjing, China. [8]Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [9]Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China. [10]The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, China. [11]Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou, China. [12]Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. [13]Department of General Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science. Institute of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. [14]Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Shandong First Medical University, Jinan, China. [15]Department of Colorectal Surgery, Shanghai Changhai Hospital, Naval Medical University. Shanghai, China. [16]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
出处：
DOI： 10.1097/DCR.0000000000003097
ISSN：

摘要：
Studies on the grade 2 rectal neuroendocrine tumors are limited and the optimal treatment for these tumors is not well established.To compare the oncologic results of local excision versus radical resection for the treatment of grade 2 rectal neuroendocrine tumors.Retrospective multicenter propensity score-matched study to minimize heterogeneity between groups and focus on the difference between surgery strategies.Seventeen Chinese large-scale medical centers participated in this study.A total of 144 patients with pathologically confirmed grade 2 rectal neuroendocrine tumors were retrospectively analyzed.Cancer-specific survival and relapse-free survival were assessed to compare surgery strategies.A total of 144 patients with grade 2 rectal neuroendocrine tumors were enrolled in this study. Twenty-seven patients underwent endoscopic resection, 55 underwent transanal excision, 50 underwent radical resection, and 12 underwent palliative surgery or biopsy for distant metastasis. Of the 50 patients who underwent radical resection, 30 (60.0%) had clinically positive lymph nodes based on the histopathology results. The optimal cutoff value for tumor size to predict cancer-specific survival was 1.5 cm. In patients with grade 2 rectal neuroendocrine tumors ≤ 1.5 cm, there were no significant differences in cancer-specific survival and relapse-free survival between local excision and radical resection groups (P >0.05). In patients with grade 2 rectal neuroendocrine tumors > 1.5 cm, relapse-free survival was significantly lower in the local excision group than in the radical resection group (P = 0.04).The nature of retrospective review and relatively short follow-up period are limitations of this study.Grade 2 rectal neuroendocrine tumors have a nonnegligible rate of lymph node metastasis. Local excision is a feasible choice for tumors ≤ 1.5 cm without metastasis, while radical resection is more beneficial in those > 1.5 cm. See Video Abstract.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Colon and Rectal Surgeons.

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出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科 3 区 胃肠肝病学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科 3 区 胃肠肝病学
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出版当年[2024]版：
无
最新[2023]版：
Q1 SURGERY Q2 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
推荐引用方式(GB/T 7714)：
Zeng Xinyu,Zhang Rui,Jiang Weizhong,et al.Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis[J].Diseases Of The Colon And Rectum.2024,67(7):911-919.doi:10.1097/DCR.0000000000003097.
APA：
Zeng Xinyu,Zhang Rui,Jiang Weizhong,Li Chengguo,Yu Minhao...&Tao Kaixiong.(2024).Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis.Diseases Of The Colon And Rectum,67,(7)
MLA：
Zeng Xinyu,et al."Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis".Diseases Of The Colon And Rectum 67..7(2024):911-919

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