个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Ding, Ping'an[1,2,3] * ; Wu, Haotian[1,2,3] * ; Wu, Jiaxiang[1,2,3] * ; Li, Tongkun[1,2,3] ; He, Jinchen[1,2,3] ; Ju, Yingchao[2,3,4] ; Liu, Yueping[2,3,5] ; Li, Fang[2,3,5] ; Deng, Huiyan[2,3,5] ; Gu, Renjun[6,7] ; Zhang, Lilong[8] ; Guo, Honghai[1,2,3] ; Tian, Yuan[1,2,3] ; Yang, Peigang[1,2,3] ; Meng, Ning[9] ; Li, Xiaolong[10] ; Guo, Zhenjiang[11] ; Meng, Lingjiao[12] ; Zhao, Qun[1,2,3] ;
机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, Hebei, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, Hebei, China. [4]Animal Center of the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [5]Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [6]School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. [7]Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. [8]Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. [9]Department of General Surgery, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, China. [10]Department of General Surgery, Baoding Central Hospital, Baoding, Hebei, China. [11]General Surgery Department, Hengshui People’s Hospital, Hengshui, Hebei, China. [12]Research Center and Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
出处：
DOI： 10.1038/s41388-024-03099-w
ISSN：

摘要：
Circular RNAs (circRNAs) have emerged as key regulators of cancer occurrence and progression, as well as promising biomarkers for cancer diagnosis and prognosis. However, the potential mechanisms of circRNAs implicated in lymph node (LN) metastasis of gastric cancer remain unclear. Herein, we identify a novel N6-methyladenosine (m6A) modified circRNA, circPAK2, which is significantly upregulated in gastric cancer tissues and metastatic LN tissues. Functionally, circPAK2 enhances the migration, invasion, lymphangiogenesis, angiogenesis, epithelial-mesenchymal transition (EMT), and metastasis of gastric cancer in vitro and in vivo. Mechanistically, circPAK2 is exported by YTH domain-containing protein 1 (YTHDC1) from the nucleus to the cytoplasm in an m6A methylation-dependent manner. Moreover, increased cytoplasmic circPAK2 interacts with Insulin-Like Growth Factor 2 mRNA-Binding Proteins (IGF2BPs) and forms a circPAK2/IGF2BPs/VEGFA complex to stabilize VEGFA mRNA, which contributes to gastric cancer vasculature formation and aggressiveness. Clinically, high circPAK2 expression is positively associated with LN metastasis and poor prognosis in gastric cancer. This study highlights m6A-modified circPAK2 as a key regulator of LN metastasis of gastric cancer, thus supporting circPAK2 as a promising therapeutic target and prognostic biomarker for gastric cancer.

基金：
Hebei Provincial Major Science and Technology Special Project [23297701Z]; Beijing-Tianjin-Hebei Basic Research Cooperation Special Project [22JCZXJC00140]; Hebei Provincial Government-funded Clinical Talent Project [ZF2023047]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 遗传学 2 区 细胞生物学 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 遗传学 2 区 细胞生物学 2 区 肿瘤学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY Q1 GENETICS & HEREDITY Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, Hebei, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, Hebei, China.
共同第一作者：
通讯作者：
通讯机构： [1]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, Hebei, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, Hebei, China.
推荐引用方式(GB/T 7714)：
Ding Ping'an,Wu Haotian,Wu Jiaxiang,et al.N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer[J].ONCOGENE.2024,43(34):2548-2563.doi:10.1038/s41388-024-03099-w.
APA：
Ding, Ping'an,Wu, Haotian,Wu, Jiaxiang,Li, Tongkun,He, Jinchen...&Zhao, Qun.(2024).N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.ONCOGENE,43,(34)
MLA：
Ding, Ping'an,et al."N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer".ONCOGENE 43..34(2024):2548-2563

资源点击量：39770 今日访问量：0 总访问量：1333 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 河北医科大学第四医院 技术支持：重庆聚合科技有限公司 地址：河北省石家庄市健康路12号