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Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial

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收录情况： ◇ SCIE

作者：
Tian Yuan[1,2,3] * ; Pang Yue[1,2,3] ; Yang Peigang[1,2,3] ; Guo Shuo[4] ; Ma Wenqian[4] ; Guo Honghai[1,2,3] ; Liu Yang[1,2,3] ; Zhang Ze[1,2,3] ; Ding Pingan[1,2,3] ; Zheng Tao[1,2,3] ; Li Yong[1,2,3] ; Fan Liqiao[1,2,3] ; Zhang Zhidong[1,2,3] ; Wang Dong[1,2,3] ; Zhao Xuefeng[1,2,3] ; Tan Bibo[1,2,3] ; Liu Yu[1,2,3] ; Zhao Qun[1,2,3] ;
机构： [1]Third Surgery Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, 050011, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, 050011, China. [4]Department of Endoscopy, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
出处：
DOI： 10.1097/JS9.0000000000001873
ISSN：

关键词： Carbon nanoparticle suspension injection Indocyanine green Lymphatic navigation technique Lymph node dissection Radical gastrectomy

摘要：
Carbon nanoparticle suspension injection (CNSI) and indocyanine green (ICG) have both been applied intraoperatively to facilitate lymphatic mapping and postoperatively to sort lymph nodes (LNs) in gastric cancer patients. However, no study has compared the two tracers in gastric cancer patients.This prospective randomized controlled trial was conducted from January 2022 to March 2023. Patients with potentially resectable gastric cancer (cT1-4a N0/+ M0) were randomized to the CNSI or ICG group.This study enrolled 96 patients. Ninety patients were in the modified intention-to-treat population, including 46 patients (32 males and 14 females; mean [SD] age, 57.4 [9.4] years) in the CNSI group and 44 patients (31 males and 13 females; mean [SD] age, 60.8 [8.8] years) in the ICG group. The mean (SD) number of retrieved LNs was 69.8 (21.9) and 53.6 (17.2) in the CNSI and ICG groups, respectively (P<0.001). The mean (SD) number of retrieved micro-LNs was 19.9 (13.3) and 11.6 (9.9) in the CNSI and ICG groups, respectively (P=0.001). The mean (SD) number of metastatic LNs was 8.1 (11.9) and 5.2 (9.2) in the CNSI and ICG groups, respectively (P=0.19).Compared with ICG, CNSI can increase the number of LNs detected, especially micro-LNs. Both tracers have high diagnostic value for detecting metastatic LNs. CNSI-guided lymphography may be a superior method for improving the accuracy of LN dissection.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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中科院分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科
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出版当年[2023]版：
Q1 SURGERY
最新[2023]版：
Q1 SURGERY

影响因子： 最新[2023版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Third Surgery Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, 050011, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, 050011, China.
通讯作者：
通讯机构： [1]Third Surgery Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. [2]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, 050011, China. [3]Big data analysis and mining application for precise diagnosis and treatment of gastric cancer Hebei Provincial Engineering Research Center, Shijiazhuang, 050011, China.
推荐引用方式(GB/T 7714)：
Tian Yuan,Pang Yue,Yang Peigang,et al.Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial[J].International Journal Of Surgery (London, England).2025,111(1):609-616.doi:10.1097/JS9.0000000000001873.
APA：
Tian Yuan,Pang Yue,Yang Peigang,Guo Shuo,Ma Wenqian...&Zhao Qun.(2025).Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial.International Journal Of Surgery (London, England),111,(1)
MLA：
Tian Yuan,et al."Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial".International Journal Of Surgery (London, England) 111..1(2025):609-616

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