机构：[1]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of MedicalSciences, No.440, Jiyan Road, Huaiyin distract, Jinan 250117, ShandongProvince, China[2]Department of Oncology, Yankuang New Journey GeneralHospital, Zoucheng 273500, China[3]Department of Radiation Oncology,Radiation Oncology Key Laboratory of Sichuan Province, Sichuan CancerCenter, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China四川省肿瘤医院[4]Department of Radiation Oncology,Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai 200050, China[5]Department of Radiation Oncology, Sun Yatsen University Cancer Center, Guangzhou 510060, China[6]Key Laboratoryof Cancer Prevention and Therapy, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin’s ClinicalResearch Center for Cancer, Tianjin 300060, China[7]Department of ThoracicSurgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute, CollaborativeInnovation Center for Cancer Medicine, Guangzhou 510060, China[8]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University,Shijiazhuang 050017, China河北医科大学第四医院[9]Department sixth of Radiotherapy, AnyangCancer Hospital, The Fourth Afliated Hospital of Henan University of Scienceand Technology, Anyang 455001, China[10]Department of Radiation Oncology,Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & NanjingMedical University Afliated Cancer Hospital, Nanjing 210009, China
BackgroundThis study aimed to establish a consensus on the delineation of target volumes for neoadjuvant radiation therapy (nRT) in esophageal squamous cell carcinoma (ESCC) within China. MethodsFrom February 2020 to June 2021, nine ESCC patients who received nRT were retrospectively selected from Sun Yat-sen University Cancer Center and Shandong Cancer Hospital. A panel from eight cancer radiotherapy centers performed two rounds of nRT target volume delineation for these patients: the first round for cases 1-6 and the second for cases 7-9. Online meetings were held after each delineation round to discuss findings. The consistency of delineations across centers was compared using mean undirected Hausdorff distances (Hmean), dice similarity coefficients (DSC), and total volumes, analyzed with the Mann-Whitney U test. ResultsThe second round of delineations showed improved consistency across centers (total clinical target volume (CTVtotal): mean DSC = 0.76-0.81; mean Hmean = 2.11-3.14 cm) compared to the first round (CTVtotal: mean DSC = 0.63-0.64; mean Hmean = 5.66-7.34 cm; DSC and Hmean: P < 0.050 between rounds), leading to the formation of a consensus and an atlas for ESCC nRT target volume delineation. A proposal was reached through evaluating target volume delineations, analyzing questionnaire survey outcomes, and reviewing pertinent literature. ConclusionsWe have developed guidelines and an atlas for target volume delineation in nRT therapy for ESCC in China. These resources are designed to facilitate more consistent delineation of target volumes in both clinical practice and clinical trials.
基金：
This work was supported by the National Natural Science Foundation of China
(grant number: 81773232); the Academic Promotion Program of Shandong
First Medical University (grant number: 2020RC002); the Project of Young
Taishan Scholars (grant number: Tsqn201909187), and the Wu Jieping Medical
Foundation (grant number: 320.6750.2021-01-11).
第一作者机构：[1]Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of MedicalSciences, No.440, Jiyan Road, Huaiyin distract, Jinan 250117, ShandongProvince, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Han Dan,Dong Jinling,Wang Qifeng,et al.Neoadjuvant radiation target volume definition in esophageal squamous cell cancer: a multicenter recommendations from Chinese experts[J].BMC CANCER.2024,24(1):doi:10.1186/s12885-024-12825-2.
APA：
Han, Dan,Dong, Jinling,Wang, Qifeng,Li, Baosheng,Liu, Jun...&Huang, Wei.(2024).Neoadjuvant radiation target volume definition in esophageal squamous cell cancer: a multicenter recommendations from Chinese experts.BMC CANCER,24,(1)
MLA：
Han, Dan,et al."Neoadjuvant radiation target volume definition in esophageal squamous cell cancer: a multicenter recommendations from Chinese experts".BMC CANCER 24..1(2024)
