机构：[1]Hebei Provincial Cancer Institute, Shijiazhuang, Hebei 050011, China.临床科室河北省肿瘤研究所河北医科大学第四医院[2]Department of Anesthesiology, the third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.[3]Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China.
A large number of studies on the metabolism of immune cells in anti-tumor response have been carried out in recent years. It is proved that metabolic reprogramming can determine the differentiation and functions of immune cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells in the tumor microenvironment (TME). They can significantly inhibit the anti-tumor response of T cells and play an important role in promoting tumor growth, metastasis, and invasion. This review summarizes the energy metabolic pathways of MDSCs in the TME, such as fatty acid oxidation (FAO), glycolysis, and amino acids (AAs) metabolism, and highlights the importance of metabolic reprogramming of MDSCs for its immunosuppressive functions.
第一作者机构：[1]Hebei Provincial Cancer Institute, Shijiazhuang, Hebei 050011, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Liang,Huo Shuping,Liu Jianghui,et al.Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment[J].Discovery Medicine.2021,31(164):141-146.
APA：
Liu Liang,Huo Shuping,Liu Jianghui,Li Qiaomin&Wang Jing.(2021).Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment.Discovery Medicine,31,(164)
MLA：
Liu Liang,et al."Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment".Discovery Medicine 31..164(2021):141-146
