机构：[1]Department of Anesthesiology, the third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.[2]Hebei Provincial Cancer Institute, Shijiazhuang 050011, Hebei, China.临床科室河北省肿瘤研究所河北医科大学第四医院[3]Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei, China.
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摘要：
Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in cancer. Long non-coding RNAs (lncRNAs) are untranslated functional RNA molecules. There is growing evidence that lncRNAs are involved in modulating transcriptional factors to become complex regulatory networks that regulate the immune function and activity of MDSCs in the immunosuppressive tumor microenvironment. This review focuses on the emerging role of lncRNAs in MDSCs activity. We summarize how lncRNAs modulate the differentiation, expansion, and immunosuppressive functions of MDSCs and the underlying mechanisms. It is hoped that lncRNAs targeting may prevent the growth and development of MDSCs in the immunosuppressive tumor microenvironment.
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外文
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中科院分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Anesthesiology, the third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
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推荐引用方式(GB/T 7714)：
Huo Shuping,Liu Liang,Li Qiaomin,et al.Modulation of Myeloid-derived Suppressor Cells by Long Non-coding RNAs in the Tumor Microenvironment and Tumorigenesis[J].Discovery Medicine.2022,33(170):143-151.
APA：
Huo Shuping,Liu Liang,Li Qiaomin&Wang Jing.(2022).Modulation of Myeloid-derived Suppressor Cells by Long Non-coding RNAs in the Tumor Microenvironment and Tumorigenesis.Discovery Medicine,33,(170)
MLA：
Huo Shuping,et al."Modulation of Myeloid-derived Suppressor Cells by Long Non-coding RNAs in the Tumor Microenvironment and Tumorigenesis".Discovery Medicine 33..170(2022):143-151
