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Comprehensive characterization of early-onset lung cancer, in Chinese young adults

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Tian Ye[1] * ; Ma Rui[1] * ; Zhao Wenchang[2] * ; Wang Shumin[3] ; Zhou Chuanjiang[4] ; Wu Weibing[5] ; Yang Bo[6] ; Xin Hua[7] ; Wang Hongyan[8] ; Li Pengfei[9] ; Li Ranhua[10] ; Liu Changhong[11] ; Lu Yao[1] ; Yu Qian[1] ; Song Chengyang[1] ; Zhang Han[2] ; Liang Ruipu[2] ; Zhang Lei[1] ; Zhou Di[1] ; Zhao Xitong[1] ; Wu Zhuo[1] ; Qi Yafei[12] ; Wang Rui[13] ; Fei Teng[14] ; Yang Xueying[15] ;
机构： [1]Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. [2]Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, China. [3]Department of Thoracic Surgery, General Hospital of Northern Theater Command, Shenyang, China. [4]Department of Thoracic Surgery, Benxi Central Hospital, Benxi, China. [5]Department of Thoracic Surgery, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [6]Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China. [7]Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. [8]Department of Thoracic Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China. [9]Department of Thoracic Surgery, Yanan Center Hospital, Yanan, China. [10]Department of Thoracic Surgery, Kunming Medical University First Affiliated Hospital, Kunming, China. [11]Department of Thoracic Surgery, The Second Hospital of Dalian Medical University, Dalian, China. [12]Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China. [13]Department of Pathology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. [14]Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, China. [15]Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
出处：
DOI： 10.1038/s41467-025-57309-4
ISSN：

摘要：
Early-onset lung cancer in young adults represents a less studied clinical entity with increasing incidence which still affects a large number of cancer patients. Here we perform a comprehensive analysis of early-onset lung cancer for the clinicopathological features, genomic alterations, gene expression, and immune landscape by establishing a cohort enrolling 421 non-small cell lung cancer (NSCLC) patients from ten medical centers in China. Comparative analysis reveals a distinct genomic alteration between younger and elder patients with NSCLC, with ERBB2 mutations and ALK-rearrangement strikingly more frequent in younger group. Transcriptome profiling indicates altered cellular metabolism and immune-related genes in tumors from younger patients. Immunological analysis reveals a decreased infiltration of immune cells (notably T cells) in tumors from younger patients. Cellular and mechanistic studies show that the prevalent ERBB2 mutants in cancer from younger patients can indeed drive tumorigenesis by elevating AKT signaling. Importantly, meta-analysis of clinical trials and our clinical practice further validate the promise of HER2-targeted therapy to treat early-onset NSCLC in East Asian patients. Our comprehensive and integrative analysis not only reveal multiple unrecognized characteristics of early-onset lung cancer, but also inform actionable therapeutics to manage this type of cancer.© 2025. The Author(s).

基金：
Scientific Research Foundation of Education Department of Liaoning Province [JCZR2020016]; Key Program of Liaoning Provincial Department of Science and Technology Foundation [2020JH2/10300060]; National Natural Science Foundation of China [32470673]; The 111 Project [B16009]; Construction Project of Liaoning Provincial Key Laboratory, China [2022JH13/10200026]
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外文
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出版当年[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区：
出版当年[2024]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2024]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
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推荐引用方式(GB/T 7714)：
Tian Ye,Ma Rui,Zhao Wenchang,et al.Comprehensive characterization of early-onset lung cancer, in Chinese young adults[J].NATURE COMMUNICATIONS.2025,16(1):doi:10.1038/s41467-025-57309-4.
APA：
Tian Ye,Ma Rui,Zhao Wenchang,Wang Shumin,Zhou Chuanjiang...&Yang Xueying.(2025).Comprehensive characterization of early-onset lung cancer, in Chinese young adults.NATURE COMMUNICATIONS,16,(1)
MLA：
Tian Ye,et al."Comprehensive characterization of early-onset lung cancer, in Chinese young adults".NATURE COMMUNICATIONS 16..1(2025)

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