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Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation

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机构: [1]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [2]National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan. [3]Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China. [4]Institut de Cancérologie de l'Ouest (ICO) - René Gauducheau, Saint-Herblain, France. [5]The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [6]West China Hospital, Sichuan University, Chengdu, China. [7]Gustave Roussy, Department of Medical Oncology, Thoracic Group, Villejuif, France; Faculty of Medicine, Paris-Saclay University, Paris, France. [8]Zhejiang Cancer Hospital, Hangzhou, China. [9]The First Hospital of China Medical University, Shenyang, China. [10]The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China. [11]CHU Hôpital de la Timone, Marseille, France. [12]CHU de Toulouse - Hôpital Larrey, Toulouse, France. [13]Central Hospital Affiliated to Shandong First Medical University, Jinan, China. [14]Beijing Chest Hospital, Capital Medical University, Beijing, China. [15]Shanxi Provincial Cancer Hospital, Taiyuan, China. [16]The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [17]Hunan Cancer Hospital, Changsha, China. [18]The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. [19]Peking University Third Hospital, Beijing, China. [20]The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [21]Jilin Cancer Hospital, Changchun, China. [22]Army Medical Center of PLA, Chongqing, China. [23]H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. [24]Centre Georges François Leclerc, Dijon, France. [25]Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. [26]Institut Catala d'Oncologia de Girona (ICO Girona), Girona, Spain. [27]The Second Affiliated Hospital of Nanchang University, Nanchang, China. [28]Harbin Medical University Cancer Hospital, Harbin, China. [29]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [30]The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. [31]University of Colorado Hospital, Anschutz Cancer Pavilion, Aurora, CO, USA. [32]Chongqing Cancer Hospital, Chongqing, China. [33]The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. [34]Yunnan Cancer Hospital, Kunming, China. [35]Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. [36]Blacktown Hospital, Sydney, NSW, Australia. [37]University of California, San Diego (UCSD), Moores Cancer Center, La Jolla, CA, USA. [38]University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center, Orange, CA, USA. [39]Chongqing University Cancer Hospital, Chongqing, China. [40]Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. [41]The First Affiliated Hospital of Nanchang University, Nanchang, China. [42]The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [43]The Second Hospital of Anhui Medical University, Hefei, China. [44]Fudan University Shanghai Cancer Center, Shanghai, China. [45]The First Affiliated Hospital of Soochow University, Suzhou, China. [46]Dizal Pharmaceutical, Shanghai, China. [47]Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. [48]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: mengzhaowang@sina.com.
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This is a report of biomarker analysis for sunvozertinib, a leading epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting EGFR exon 20 insertion mutation (exon20ins) non-small cell lung cancer (NSCLC). There is a positive correlation between positive EGFR exon20ins in plasma circulating tumor DNA (ctDNA) and advanced disease. Shorter progression-free survival and lower objective response rate (45.8% vs. 68.0%) were observed in patients with positive EGFR exon20ins compared to those with negative status. Droplet digital PCR analysis showed that the EGFR exon20ins allele in ctDNA decreased over time in 85.7% of patients, with the earliest clearance occurred after 1 week of sunvozertinib treatment. Acquired EGFR C797S is identified as a potential on-target resistance mutation to sunvozertinib. Finally, efforts are undertaken to investigate therapeutic approaches that aim to overcome the putative acquired resistance to sunvozertinib.Copyright © 2025. Published by Elsevier Inc.

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出版当年[2025]版:
大类 | 1 区 医学
小类 | 1 区 医学:研究与实验 2 区 细胞生物学
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 医学:研究与实验 2 区 细胞生物学
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出版当年[2024]版:
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版:
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2024版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

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第一作者机构: [1]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
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