Retinal neovascularization (NV) is a major cause of the blindness associated with such ischemic retinal disorders as diabetic retinopathy, retinopathy of prematurity and retinal occlusion. Neovascularization is induced by complex interactions among growth factors and cytokines. Some studies confirm that VEGF play a central role in neovascularization, there remain some questions as to why VEGF antagonists are only partially effective. Transforming growth factor-beta (TGF-beta) has been implicated in the development of neovascularization (Gerard et al. 2000). Smad 4 plays the most important role in the TGF-beta signal transduction (Zimowska 2006). In this study, we used the model of oxygen-induced retinopathy in neonatal mice to investigate the expression of TGF-beta 1 and Smad 4 mRNA in the retina, to explore their role in the development of retinal neovascularization.
第一作者机构：[2]Chongqing Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Phys Ctr, Chongqing 400016, Peoples R China
通讯作者：
通讯机构：[1]Sichuan Prov Peoples Hosp, Dept Ophthalmol, Chengdu 610072, Sichuan, Peoples R China[2]Chongqing Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Phys Ctr, Chongqing 400016, Peoples R China
推荐引用方式(GB/T 7714)：
Fan Yingchuan,Lei Chuntao,Chen Hui,et al.Increased Expression of TGF-beta 1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice[J].RETINAL DEGENERATIVE DISEASES: LABORATORY AND THERAPEUTIC INVESTIGATIONS.2010,664:71-77.doi:10.1007/978-1-4419-1399-9_9.
APA：
Fan Yingchuan,Lei Chuntao,Chen Hui&Hu Jianbin.(2010).Increased Expression of TGF-beta 1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice.RETINAL DEGENERATIVE DISEASES: LABORATORY AND THERAPEUTIC INVESTIGATIONS,664,
MLA：
Fan Yingchuan,et al."Increased Expression of TGF-beta 1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice".RETINAL DEGENERATIVE DISEASES: LABORATORY AND THERAPEUTIC INVESTIGATIONS 664.(2010):71-77
