机构：[1]Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, You Yi Rd, Chongqing 400016, Peoples R China重庆医科大学附属第一医院[2]Loma Linda Univ Med Ctr, Dept Neurosurg, Loma Linda, CA 92354 USA
Subarachnoid hemorrhage (SAH) is an important cause of death and disability worldwide. To date, there is not a definitive treatment that completely prevents brain injury after SAH. Recently, early brain injury (EBI) has been pointed out to be the primary cause of mortality in SAH patients. Apoptosis that occurs in neuronal tissues and cerebral vasculature after SAH plays an essential role in EBI. Matrix metalloproteinase 9 (MMP-9) has been found to increase in many cerebral vascular diseases. There have been reports that MMP-9 can mediate apoptosis, which called anoikis in cerebral ischemia models, through cleaving main components of the extracellular matrix (ECM), especially laminin. Therefore, minocycline, which has been found to inhibit MMP-9, may be protective to brain injury after SAH. We based our hypothesis on the fact that SAH possesses some aspects that are similar to those of cerebral ischemia. It is conceivable that MMP-9 may also be involved in the pathological process of EBI after SAH, and minocycline can relieve anoikis and improve EBI after SAH.
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第一作者：
第一作者机构：[1]Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, You Yi Rd, Chongqing 400016, Peoples R China
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推荐引用方式(GB/T 7714)：
Guo Zong-duo,Sun Xiao-chuan,Zhang John H..Mechanisms of Early Brain Injury After SAH: Matrixmetalloproteinase 9[J].EARLY BRAIN INJURY OR CEREBRAL VASOSPASM, VOL 1: PATHOPHYSIOLOGY.2011,110:63-+.doi:10.1007/978-3-7091-0353-1_11.
APA：
Guo, Zong-duo,Sun, Xiao-chuan&Zhang, John H..(2011).Mechanisms of Early Brain Injury After SAH: Matrixmetalloproteinase 9.EARLY BRAIN INJURY OR CEREBRAL VASOSPASM, VOL 1: PATHOPHYSIOLOGY,110,
MLA：
Guo, Zong-duo,et al."Mechanisms of Early Brain Injury After SAH: Matrixmetalloproteinase 9".EARLY BRAIN INJURY OR CEREBRAL VASOSPASM, VOL 1: PATHOPHYSIOLOGY 110.(2011):63-+
