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Genetic polymorphisms of N-acetyltransferase 2 and colorectal cancer risk

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机构: [1]Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China [2]Department of Surgery, No. 4 Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China [3]Laboratory of HLA, Hebei Province Blood Center, Shijiazhuang 050071, Hebei Province, China [4]Department of Oncology, Institute of Biomedicine and Surgery, University of Link(o)ping, S-581 85 Link(o)ping, Sweden
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关键词: NAT2 gene Colorectal cancer RFLP

摘要:
AIM: To identify the distribution of N-acetyltrasferase 2(NAT2) polymorphism in Hebei Han Chinese and the effects of the polymorphism on the development of colorectal cancer.METHODS: We performed a hospital-based case-control study of 237 healthy individuals and 83 colorectal cancer patients of Hebei Han Chinese. DNA was extracted from peripheral blood and cancer tissues. The genotypes of the polymorphisms were assessed by PCR-restriction fragment length polymorphism(RFLP).RESULTS: There were four NAT2 alleles of WT, M1, M2,and M3 both in the healthy subjects and in the patients,and 10 genotypes of WT/WT, WT/M1, WT/M2, WT/M3,M1/M1, M1/M2, M1/M3, M2/M2, M2/M3, M3/M3. M2 allelewas present in 15.61% of healthy subjects and 29.52%of patients (χ2= 15.31, P<0.0001), and M3 allele was present in 30.59% of healthy subjects and 16.87% of patients (χ2 = 25.33, P<0.0001). There were more WT/M2(χ2 = 34.42, P<0.0001, odd ratio = 4.99, 95%CI = 2.27-9.38)and less WT/M3 (χ2= 3.80, P= 0.03)in the patients than in the healthy subjects. In 70.3% of the patients, there was a difference in NAT2 genotype between their tumors and blood cells. Patients had more WT/M2 (χ2= 5.11,P = 0.02) and less M2/M3 (χ2= 4.27, P = 0.039) in their blood cells than in the tumors. Furthermore, 53.8% (7/13)of M2/M3 in tumors were from WT/M2 of blood cells.CONCLUSION: There is a possible relationship between the NAT2 polymorphisms and colorectal cancer in Hebei Han Chinese. The genotype WT/M2 may be a risk factor for colorectal cancer.

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大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
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第一作者机构: [1]Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
通讯作者:
通讯机构: [1]Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China [*1]Depatment of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
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