Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma
机构：[1]Cancer Center, Hebei Cancer Institute and the Fourth Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China,临床科室河北省肿瘤研究所河北医科大学第四医院[2]Faculty of Medicine, School of Clinical Medicine, HeBei University, Baoding, China,[3]Medical Imaging, Hospital of Sinopec Shengli Oilfield, Dongying, China,[4]Department of Medical Image, Hebei Tumor Hospital and the Fourth Hospital of Hebei Medical University, Shijiazhuang, China,河北医科大学第四医院[5]Department of Medical Information, Affiliated Hospital of Niigata University, Niigata, Japan
Background In China, esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) differ in terms of multiple primary cancer (MPC) and male-to-female sex ratio (MFSR). Methods We studied site-specific variation in familial cancer by comparing family history (FH), MPC, age at onset (AO), and MFSR among 8768 patients with ESCC/GCA. Results ESCC/GCA patients with a positive FH are associated with a significantly higher rate of MPC and a younger AO than those without (sex-specifically: MPC 1.6% vs. 0.7%, P<0.01 and 3.2% vs. 0.8%, P<0.01; AO 53.1 +/- 8.1 vs. 54.5 +/- 8.2, P=0.000 and 52.9 +/- 7.4 vs. 54.0 +/- 8.0, P=0.005). Among patients with a positive FH, MPC decreases significantly from upper-, middle-, and lower-third ESCC to GCA (sex-specifically: 53.6%, 1.8%, 1.6%, 0.8%, P=0.000; and 71.4%, 1.5%, 2.2%, 1.6%, P=0.000). From MPC, upper-, middle-, and lower-third ESCC to GCA, AO increased sex-specifically: 51.9 +/- 7.2, 52.8 +/- 7.9, 52.1 +/- 8.3, 54.3 +/- 8.4, 55.6 +/- 7.6 (P=0.000) and 49.3 +/- 6.5, 51.8 +/- 9.8, 52.6 +/- 7.8, 54.4 +/- 8.0, 55.7 +/- 7.2 (P=0.000), and FH decreased: 43.8%, 35.1%, 28.2%, 29.5%, 24.4% (P=0.000) and 55.2%, 26.7%, 25.0%, 24.3%, 22.3% (P=0.000). The preponderance of males, smoking, alcohol consumption, and patients >= 50 years old increased from 2.2:1, 1.7:1, 1.0:1, 2.0:1 in ESCC to 6.1:1, 2.8:1, 2.5:1, 4.0:1 in GCA, yet more MPCs were associated with non-preponderant than preponderant counterparts; particularly in GCA, the difference was statistically significant. Conclusion The proportion of familial cancer may decrease from upper-, middle-, and lower-third ESCC to GCA. This entails molecular investigation, and appreciating this may help us devise a better screening strategy or individualize cancer treatment.
基金：
This work was partially supported by a grant for Key subject
development for universities of Hebei Province (No. 03276198D).
第一作者机构：[1]Cancer Center, Hebei Cancer Institute and the Fourth Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China,
共同第一作者：
通讯作者：
通讯机构：[1]Cancer Center, Hebei Cancer Institute and the Fourth Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China,
推荐引用方式(GB/T 7714)：
Wen Denggui,Wen Junpeng,Zou Wendi,et al.Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma[J].FRONTIERS IN ONCOLOGY.2020,10:doi:10.3389/fonc.2020.579379.
APA：
Wen, Denggui,Wen, Junpeng,Zou, Wendi,Yang, Yi,Wen, Xiaoduo...&Shan, Baoen.(2020).Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma.FRONTIERS IN ONCOLOGY,10,
MLA：
Wen, Denggui,et al."Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma".FRONTIERS IN ONCOLOGY 10.(2020)
