机构：[1]Department of Basic Medicine, Inner Mongolia Medical University, Jinshan Development Zone, Huhhot, Inner Mongolia, P.R. China,[2]Department of Orthopedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center, Memphis, TN, USA,[3]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei,河北医科大学第四医院[4]Beijing Cancer Hospital and Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing, P.R. China,[5]Department of Medicine, Division of Connective Tissue Diseases, The University of Tennessee Health Science Center,[6]Research Service, Memphis VA Medical Center, Memphis, TN, USA.
Introduction: Smoking is well-known to increase cancer risk, particularly risk of lung cancer, and negatively affects efficacy of cancer treatment. However, recent evidence suggests that among cancer patients, paradoxically, smokers respond to treatment better than non-smokers. We propose to conduct a focused review and meta-analysis to compare response to drug treatment between smoking and non-smoking cancer patients. Methods and design: We will collect data from large clinical trials of therapies for cancer patients which have included smokers and non-smokers. We will search PubMed, PMC/ MEDLINE, SCOPUS, Embase, and the registries for clinical trials and four major clinical journals up to June 30, 2019. Search terms will be "Drug name" phase-3" or "Drug name" phase-III." Data collection will be focused on randomized clinical trials of cancer drugs that enrolled at least 100 participants and reporting treatment results from smoking and nonsmoking patients. Initial selection criteria will be clinical trial studies of drug treatment of 100 or more cancer patients, and reporting hazard ratios (HR) for smokers and non-smokers. Two persons will be searching such publications independently, or data will be provided, double checked, or confirmed by authors. Multiple sub-group analyses will be conducted by at least two persons to avoid bias or experimental errors. Discussion: The results will clarify whether smoking and response to treatment of cancer are linked not. Our results may possibly identify drug/s that work better among cancer patients who are smokers.
基金：
The study was partially supported by grants from the Gene discovery Core at UTHSC; the Veterans Administration Medical Center in Memphis, TN; a merit award (I01
BX000671 to WG) from the Department of Veterans’ Affairs; a grant from Beijing Jinkailu International Education Technology (R073290143); support from Hebei
Medical University, and the Goodman Chair of Excellence at University of Tennessee Health Science Center (AP).
第一作者机构：[1]Department of Basic Medicine, Inner Mongolia Medical University, Jinshan Development Zone, Huhhot, Inner Mongolia, P.R. China,[2]Department of Orthopedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center, Memphis, TN, USA,
共同第一作者：
通讯作者：
通讯机构：[2]Department of Orthopedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center, Memphis, TN, USA,[3]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei,[6]Research Service, Memphis VA Medical Center, Memphis, TN, USA.[*1]Department of Orthopedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center College of Medicine, Memphis, TN 38103, USA[*2]Research Center, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Wang Lishi,Feng Helin,Li Jing,et al.Responses of smoking and nonsmoking cancer patients to drug treatment A protocol for systematic review and meta-analysis[J].MEDICINE.2020,99(38):doi:10.1097/MD.0000000000022104.
APA：
Wang, Lishi,Feng, Helin,Li, Jing,Liu, FengXia,Liu, Qingyi...&Shan, Baoen.(2020).Responses of smoking and nonsmoking cancer patients to drug treatment A protocol for systematic review and meta-analysis.MEDICINE,99,(38)
MLA：
Wang, Lishi,et al."Responses of smoking and nonsmoking cancer patients to drug treatment A protocol for systematic review and meta-analysis".MEDICINE 99..38(2020)
