机构：[1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China临床科室肿瘤免疫科河北医科大学第四医院[2]Department of Oncology, Affiliated Xingtai People’s Hospital of Hebei Medical University, Xingtai 054001, China[3]Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China临床科室泌尿外科河北医科大学第四医院[4]School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China[5]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China河北医科大学第四医院
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer. ccRCC arises from the proximal tubular epithelium and is associated with high mortality. Autophagy may either promote or suppress tumor cell survival at different stages of cancer development. It is essential to investigate the association between autophagy-related genes (ARGs) and prognosis in ccRCC patients. We used datasets obtained from The Cancer Genome Atlas (TCGA) database to identify the expression level of ARGs in ccRCC patients. Functional enrichment and Kyoto Encyclopedia of Genes and Genomes (K EGG) analyses were performed using Metascape database. Hub genes were identified by Cytoscape software. We constructed a Cox proportional hazard regression model to identify hub genes that are significantly associated with overall survival (OS) in ccRCC patients. Subsequently, a prognostic index (PI) was calculated and ccRCC patients were stratified into high-risk and low-risk groups based on a median PI value. Our study detected several altered ARGs in ccRCC, which could be a useful prognostic tool in ccRCC patients.
第一作者机构：[1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China[2]Department of Oncology, Affiliated Xingtai People’s Hospital of Hebei Medical University, Xingtai 054001, China
通讯作者：
通讯机构：[1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China[*1]Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
推荐引用方式(GB/T 7714)：
Jin Yi,Li Feng,Guo Peiyuan,et al.Identification of an individualized autophagy prognostic index in clear cell renal cell carcinoma patients[J].TRANSLATIONAL CANCER RESEARCH.2020,9(4):2951-2961.doi:10.21037/tcr.2020.03.06.
APA：
Jin, Yi,Li, Feng,Guo, Peiyuan,Dong, Keqin,Guo, Peng...&Wang, Zhiyu.(2020).Identification of an individualized autophagy prognostic index in clear cell renal cell carcinoma patients.TRANSLATIONAL CANCER RESEARCH,9,(4)
MLA：
Jin, Yi,et al."Identification of an individualized autophagy prognostic index in clear cell renal cell carcinoma patients".TRANSLATIONAL CANCER RESEARCH 9..4(2020):2951-2961
