机构：[1]Department of Medical Oncology, THe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China临床科室肿瘤内科河北医科大学第四医院[2]Second Department of Surgery, THe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China临床科室外二科河北医科大学第四医院[3]Department of THoracic Surgery, THe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China临床科室胸心外科（胸外科 心脏血管外科）河北医科大学第四医院
Purpose. Colon adenocarcinoma (COAD) is the third most common malignancy globally and is further categorized as left colon adenocarcinoma (LCOAD) or right colon adenocarcinoma (RCOAD) depending on the location of the primary tumor. The therapeutic outcome and long-term prognosis for patients with COAD are less than satisfactory, and this may be associated with tumor location. Therefore, it is important to investigate the genetic differences in COAD at different sites. Patients and Methods. Public data associated with COAD were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using R software (version 3.5.3), and functional annotation of DEGs was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. A protein-protein interaction network was constructed, hub genes were identified and analyzed, and data mining using Gene Expression Profiling Interactive Analysis (GEPIA) was conducted. Results. A total of 286 DEGs were identified between LCOAD and RCOAD. Additionally, 10 hub genes associated with COAD at different locations were screened, namely, CDKN2A, IGF1R, MDM2, SMAD3, SLC2A1, GRM5, PLCB4, FGFR1, UBE2V2, and TNFRSF10B. The expression of cyclin-dependent kinase inhibitor 2A (CDKN2A) and solute carrier family 2 member 1 (SLC2A1) was significantly associated with pathological stage P<0.05. COAD patients with high expression levels of CDKN2A exhibited poorer overall survival (OS) times than those with low expression levels P<0.05. Conclusion. CDKN2A expression was significantly different between LCOAD and RCOAD and was closely related to the prognosis of COAD. It is of great value for further understanding of the pathogenesis of LCOAD and RCOAD.
基金：
THe authors are thankful to the Department of Medical
Oncology, the Fourth Hospital of Hebei Medical University,
for the assistance and support during the submission
process.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2020]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2020]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Medical Oncology, THe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
通讯作者：
推荐引用方式(GB/T 7714)：
Han Jing,Zhang Xue,Yang Yang,et al.Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma[J].BIOMED RESEARCH INTERNATIONAL.2020,2020:doi:10.1155/2020/8465068.
APA：
Han, Jing,Zhang, Xue,Yang, Yang,Feng, Li,Wang, Gui-Ying&Zhang, Nan.(2020).Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma.BIOMED RESEARCH INTERNATIONAL,2020,
MLA：
Han, Jing,et al."Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma".BIOMED RESEARCH INTERNATIONAL 2020.(2020)
