机构：[1]First Hospital of Qinhuangdao, Qinhuangdao, China[2]Department of Breast Cancer Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China临床科室外一科河北医科大学第四医院[3]Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China医技科室病理科河北医科大学第四医院
Background: To investigate the differences of clinic-pathological features among ductal carcinoma in situ (DCIS), ductal carcinoma in situ with micro-invasion (DCIS-MI) and early invasive carcinoma (IDC) in stage T1. Methods: From January 2014 to December 2018, 308 cases DCIS, DCIS-MI 92 cases and 111 cases of T1a, 343 cases of T1b, and 1032 cases of T1c were investigated in a retrospective analysis. The population and clinic-pathological characteristics including age, menstrual status, surgical mode, lymph node status and molecular markers were compared in each group. Survival rate of all patients were followed-up for 5 years. Results: Compared with DCIS-MI group, the higher breast-conserving rate and lower lymph node metastasis rate in the DCIS group were shown in the DCIS-MI group (p < .05). There were no significant differences in tumor diameter, number of tumors, ER, PR, HER2 and Ki67 expression, molecular typing, (p > .05). The expression of Ki67 in T1a, T1b and T1c groups increased gradually with elevated grades (p < .05). The proportion of HER2-positive patients in DCIS-MI group was significantly higher than that in T1a-b-c (p < .05). There were no significant differences in DFS and OS between the 3 groups (p > .05). Conclusions: The clinic-pathological features of DCIS-MI are similar to those of DCIS and T1a, but significantly different from T1c.
基金：
The study was supported by Hebei Province Science and
Technology Project [Grant no. 19277751 D]
第一作者机构：[1]First Hospital of Qinhuangdao, Qinhuangdao, China
通讯作者：
通讯机构：[2]Department of Breast Cancer Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*1]Department of Breast Cancer Center, the Fourth Hospital of Hebei Medical University, No.12, Jian- Kang Road, Shijiazhuang 050011, China.
推荐引用方式(GB/T 7714)：
Zheng Jie,Zhou Tao,Li Fang,et al.Clinic-Pathological Features of Breast Ductal Carcinoma in Situ with Micro-Invasion[J].CANCER INVESTIGATION.2020,38(2):113-121.doi:10.1080/07357907.2020.1715422.
APA：
Zheng, Jie,Zhou, Tao,Li, Fang,Shi, Jiajie&Zhang, Lina.(2020).Clinic-Pathological Features of Breast Ductal Carcinoma in Situ with Micro-Invasion.CANCER INVESTIGATION,38,(2)
MLA：
Zheng, Jie,et al."Clinic-Pathological Features of Breast Ductal Carcinoma in Situ with Micro-Invasion".CANCER INVESTIGATION 38..2(2020):113-121
