机构：[1]Department of Stomatology, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei,050017,China临床科室口腔科河北医科大学第四医院[2]Department of Pathology, Chinese Medicine Hospital in Hebei Province,Shijiazhuang, Hebei,050017,China[3]Department of Stomatology, Hebei Eye Hospital, Xingtai, Hebei 054000,China[4]Department of Stomatology, Second Hospital of Shijiazhuang, Shijiazhuang, Hebei,050000,China
The host protective immunity against viral infection requires the effective detection of viral antigens and the subsequent production of type I interferons (IFNs) by host immune cells. Retinoic acid-inducible gene I (RIG-I) is the crucial signaling element responsible for sensing viral RNA component and initiating the downstream antiviral signaling pathways, leading to the production of type I IFNs. In this work, we identified microRNA-218 (miR-218) as a new virus-induced miRNA that dampens the expression of RIG-I in mouse and human macrophages, leading to the impaired production of type I IFNs. Interfering miR-218 expression rescued RIG-I-mediated antiviral signaling and thus protected macrophages from viral infection. Hence, our results provide new understanding of miRNA-mediated viral immune evasion and may be potentially useful for the treatment of viral infection in the future.
基金：
This work was supported by Hebei key project plan of medical science research（
NO.20180597），Hebei science and technology support project（NO.132777252）.
第一作者机构：[1]Department of Stomatology, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei,050017,China
通讯作者：
通讯机构：[4]Department of Stomatology, Second Hospital of Shijiazhuang, Shijiazhuang, Hebei,050000,China[*1]Huaxi Road No.53, Shijiazhuang, Hebei,050000,China
推荐引用方式(GB/T 7714)：
Qiu Yongle,Geng Xixue,Ban Jiandong,et al.MicroRNA-218 inhibits type I interferon production and facilitates virus immune evasion via targeting RIG-I[J].BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY.2020,67(3):396-403.doi:10.1002/bab.1882.
APA：
Qiu, Yongle,Geng, Xixue,Ban, Jiandong&Liu, Yuanhang.(2020).MicroRNA-218 inhibits type I interferon production and facilitates virus immune evasion via targeting RIG-I.BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,67,(3)
MLA：
Qiu, Yongle,et al."MicroRNA-218 inhibits type I interferon production and facilitates virus immune evasion via targeting RIG-I".BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 67..3(2020):396-403
