Danshensu is a pure molecule derived from Danshen, which is the root of the herb Salvia miltiorrhiza. It has a clearly defined chemical structure and demonstrates therapeutic effects in cardiovascular diseases (e.g., myocardial ischemia and reperfusion, atherosclerosis, hypertension), cerebral lesions and disorders (e.g., ischemia, cognitive decline, and anxiety), and other health problems (e.g., thrombosis, tumorigenesis, pancreatitis). The mechanisms behind these effects include antioxidation, anti-apoptosis, vasodilation, inflammation regulation, lipidemia control, etc., through the PI3K/Akt-ERK1/2/Nrf2/HO-1, Bcl-2/Bax, eNOS and other molecular signaling pathways. Both Danshen and Danshensu might be more effective than classical cardiovascular drugs, and their combination yields improved therapeutic efficiency. Here, we provide an overview of these drugs for a better understanding of Danshensu as a promising Chinese traditional medicine.
基金：
Project of Scientific Research of Hebei Provincial Administration of Traditional Chinese Medicine [2019134]; Key Project of Medical Science Research of Hebei Province [20180594]
第一作者机构：[1]Hebei Med Univ, Dept Cardiol, Affiliated Hosp 4, 12 Hlth Rd, Shijiazhuang 050011, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Cardiol, Affiliated Hosp 4, 12 Hlth Rd, Shijiazhuang 050011, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Jinli,Zhang Qianqian,Liu Guang,et al.Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2019,864:doi:10.1016/j.ejphar.2019.172710.
APA：
Zhang, Jinli,Zhang, Qianqian,Liu, Guang&Zhang, Ning.(2019).Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu.EUROPEAN JOURNAL OF PHARMACOLOGY,864,
MLA：
Zhang, Jinli,et al."Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu".EUROPEAN JOURNAL OF PHARMACOLOGY 864.(2019)
