Objective: To investigate the incidence and risk factors of catheter misplacement in implantable vascular access devices (TIVAD), in order to reduce the occurrence of catheter misplacement. Methods: Retrospective analysis was performed to examine the incidence and risk factors of catheter misplacement in 8534 patients with TIVAD implantation. Results: The incidence of catheter misplacement in all TIVAD cases was 1.49%, and the cases with left subclavian vein puncture had the highest incidence of catheter misplacement (11.69%) (chi(2) =63.480, P=0.000). There was no significant difference in the incidence of catheter misplacement among the patients with different ages, genders or body mass index (P>0.05). Conclusion: TIVAD implantation should strictly follow the standard operation procedure, and the vascular variability in patients needs to be examined before operation. In addition, to reduce the incidence of catheter misplacement, the right internal jugular vein should be the preferred location for TIVAD.