机构：[1]Hebei Med Univ, Hosp 4, Dept Res Ctr, Shijiazhuang, Hebei, Peoples R China河北医科大学第四医院[2]Hebei Med Univ, Hosp 4, Tumor Res Inst, Shijiazhuang, Hebei, Peoples R China河北医科大学第四医院
Objective: To evaluate the clinical characteristics and prognostic significance of MAGE-A11 and transcription factors (SP1, TFCP2 and ZEB1) in patients with esophageal squamous cell carcinoma (ESCC). Methods: To assess the expression of MAGE-A11 and transcription factors (SP1, TFCP2 and ZEB1) in 121 ESCC samples were respectively detected by immunohistochemical method. Results: The results showed MAGE-All and transcription factors (SP1,TFCP2 and ZEB1) expression were associated with some clinical features in patients, such as pathological differentiation, tumor size, clinical stage, lymph node metastasis and distant metastasis. Kaplan-Meier analysis showed that patients with ESCC having high MAGE-All and transcription factors (SP1,TFCP2 and ZEB1) expression had a worse prognosis compared to the patients with low expression. Multivariate Cox proportional hazards regression model revealed that MAGE-A11 expression, TFCP2 expression, lymph node metastasis and distant metastasis were independently associated with ESCC patients' survival. Conclusions: High expression of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues suggests promoting ESCC progression and poor prognosis, co-expression of MAGE-All and transcription factors even worse.
基金：
Natural Science Foundation of Hebei Province, ChinaNatural Science Foundation of Hebei Province [H2016206410]; Financial Supporting Program of Hebei Province [[2014]1257]; Financial department of Hebei Province [361006]
第一作者机构：[1]Hebei Med Univ, Hosp 4, Dept Res Ctr, Shijiazhuang, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 4, Dept Res Ctr, Shijiazhuang, Hebei, Peoples R China[2]Hebei Med Univ, Hosp 4, Tumor Res Inst, Shijiazhuang, Hebei, Peoples R China[*1]Research Center, The Fourth Hospital of Hebei Medical University, 050017, Shijiazhuang, Hebei, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Gu Lina,Sang Meixiang,Li Juan,et al.Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues[J].PATHOLOGY RESEARCH AND PRACTICE.2019,215(7):doi:10.1016/j.prp.2019.152446.
APA：
Gu, Lina,Sang, Meixiang,Li, Juan,Liu, Fei,Wu, Yunyan...&Shan, Baoen.(2019).Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues.PATHOLOGY RESEARCH AND PRACTICE,215,(7)
MLA：
Gu, Lina,et al."Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues".PATHOLOGY RESEARCH AND PRACTICE 215..7(2019)
