机构：[1]Department of Neurology, the Second Hospital, Hebei Medical University, No. 215 Heping West Road, Xinhua District, Shijiazhuang 050000, Hebei, China[2]Department of Medical Image, the Fourth Hospital, Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei, China河北医科大学第四医院[3]Department of Pediatrics, the Fourth Hospital, Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei, China临床科室儿科河北医科大学第四医院[4]Department of Endocrinology, the Fourth Hospital, Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei, China临床科室内分泌科河北医科大学第四医院
A number of investigations have addressed the importance of high glucose in breast cancer, however, the involvement of angiotensinogen (AGT) in this scenario is yet to be defined. Here we set out to analyze the potential pro-tumor effects of high glucose in breast cancer, and understand the underlying molecular mechanism. We demonstrated that high glucose promoted cell proliferation, viability, and anchorage-independent growth of breast cancer cells. In addition, the migrative and invasive capacities were significantly enhanced by high glucose medium. Mechanistically, AGT expression was inhibited by high glucose at both transcriptional and translational levels. High AGT remarkably suppressed proliferation, inhibited viability, and compromised migration/invasion of breast cancer cells. Most importantly, ectopic introduction of AGT almost completely abrogated pro-tumor effects of high glucose. Our study has characterized the pro-tumor properties of high glucose in breast cancer cells, which is predominantly attributed to the suppression of AGT.
基金：
Youth Science and Technology Project of Scientific Research Fund of Hebei Provincial Department
of Health [grant number 20150767].
第一作者机构：[1]Department of Neurology, the Second Hospital, Hebei Medical University, No. 215 Heping West Road, Xinhua District, Shijiazhuang 050000, Hebei, China
通讯作者：
通讯机构：[4]Department of Endocrinology, the Fourth Hospital, Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei, China
推荐引用方式(GB/T 7714)：
Sun Shichao,Sun Yao,Rong Xiaoping,et al.High glucose promotes breast cancer proliferation and metastasis by impairing angiotensinogen expression[J].BIOSCIENCE REPORTS.2019,39:doi:10.1042/BSR20190436.
APA：
Sun, Shichao,Sun, Yao,Rong, Xiaoping&Bai, Lei.(2019).High glucose promotes breast cancer proliferation and metastasis by impairing angiotensinogen expression.BIOSCIENCE REPORTS,39,
MLA：
Sun, Shichao,et al."High glucose promotes breast cancer proliferation and metastasis by impairing angiotensinogen expression".BIOSCIENCE REPORTS 39.(2019)
