Exposure to environmental endocrine disruptors (EEDs) could induce high risk of cancer, obesity and depression. Fluorene-9-bisphenol (BHPF), a widely used EED, has been reported to exhibit anti-estrogenic activity and induce insomnia-like behaviors. The potential effects of BHPF exposure on emotional behaviors are still elusive. The present study aimed to investigated the neurobehavioral effects of BHPF exposure intragastrically (0.5, 5 mg kg(-1), i.g.) at different developmental stages by using behavioral tests, including open field test (OFT), novelty-suppressed feeding test (NSF), sucrose preference test (SPT), tail suspension test (TST) and forced swimming test (FST). The results showed that adulthood BHPF exposure significantly induced anxiety- and depression-like behaviors in adult male mice; exposure to BHPF during pregnancy could attenuate depression-like behaviors in female mice. Maternal BHPF exposure reduced spontaneous activity of both male and female adolescent offspring as well as male adult offspring. Besides, maternal BHPF exposure decreased depression-like behaviors in both male and female adolescent offspring, and the female adolescent offspring were more sensitive than male adolescent offspring. Maternal exposure to BHPF decreased depression-like behaviors in male adult offspring; increased depression- and anxiety-like behaviors in female adult offspring. In conclusion, these data indicated that exposure to BHPF could disrupt neurobehaviors to varying degrees at different stages in mice. (C) 2019 Elsevier Ltd. All rights reserved.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771462]; Natural Science Foundation of Hebei Province, ChinaNatural Science Foundation of Hebei Province [H2018206119]; Excellent Innovative Talents in Colleges and Universities of Hebei Province, China; Science Foundation from HFPC of Hebei Province [20170471]; Special Foundation for Excellent Undergraduate Students from Hebei Medical University [USIP2017035]; Medicine Research Foundation from HFPC of Hebei [20130544]
第一作者机构:[1]Hebei Med Univ, Inst Med & Hlth Sci HeBMU, Ctr Neurosci Res, Shijiazhuang 050017, Hebei, Peoples R China[2]Hebei Med Univ, Coll Basic Med, Shijiazhuang 050017, Hebei, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Hebei Med Univ, Inst Med & Hlth Sci HeBMU, Ctr Neurosci Res, Shijiazhuang 050017, Hebei, Peoples R China[6]Hebei Med Univ, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei, Peoples R China[7]Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identificat, Shijiazhuang 050017, Hebei, Peoples R China[*1]Center of Neuroscience Research, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China[*2]Center of Neuroscience Research, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China.
推荐引用方式(GB/T 7714):
Ji Xumeng,Shi Luling,Yin Xi,et al.Sex- and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice[J].CHEMOSPHERE.2019,225:890-896.doi:10.1016/j.chemosphere.2019.03.110.
APA:
Ji, Xumeng,Shi, Luling,Yin, Xi,Huai, Ziqing,Li, Yiming...&Shi, Haishui.(2019).Sex- and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice.CHEMOSPHERE,225,
MLA:
Ji, Xumeng,et al."Sex- and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice".CHEMOSPHERE 225.(2019):890-896