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Sex- and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice

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机构: [1]Hebei Med Univ, Inst Med & Hlth Sci HeBMU, Ctr Neurosci Res, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Coll Basic Med, Shijiazhuang 050017, Hebei, Peoples R China [3]Hebei Med Univ, Dept Funct Reg Diag, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China [4]Hebei Med Univ, Expt Educ Ctr, Clin Coll, Shijiazhuang 050017, Hebei, Peoples R China [5]Hebei Med Univ, Coll Publ Hlth, Shijiazhuang 050017, Hebei, Peoples R China [6]Hebei Med Univ, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei, Peoples R China [7]Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identificat, Shijiazhuang 050017, Hebei, Peoples R China
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关键词: Environmental endocrine disruptor Fluorene-9-bisphenol Depression Anxiety

摘要:
Exposure to environmental endocrine disruptors (EEDs) could induce high risk of cancer, obesity and depression. Fluorene-9-bisphenol (BHPF), a widely used EED, has been reported to exhibit anti-estrogenic activity and induce insomnia-like behaviors. The potential effects of BHPF exposure on emotional behaviors are still elusive. The present study aimed to investigated the neurobehavioral effects of BHPF exposure intragastrically (0.5, 5 mg kg(-1), i.g.) at different developmental stages by using behavioral tests, including open field test (OFT), novelty-suppressed feeding test (NSF), sucrose preference test (SPT), tail suspension test (TST) and forced swimming test (FST). The results showed that adulthood BHPF exposure significantly induced anxiety- and depression-like behaviors in adult male mice; exposure to BHPF during pregnancy could attenuate depression-like behaviors in female mice. Maternal BHPF exposure reduced spontaneous activity of both male and female adolescent offspring as well as male adult offspring. Besides, maternal BHPF exposure decreased depression-like behaviors in both male and female adolescent offspring, and the female adolescent offspring were more sensitive than male adolescent offspring. Maternal exposure to BHPF decreased depression-like behaviors in male adult offspring; increased depression- and anxiety-like behaviors in female adult offspring. In conclusion, these data indicated that exposure to BHPF could disrupt neurobehaviors to varying degrees at different stages in mice. (C) 2019 Elsevier Ltd. All rights reserved.

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大类 | 2 区 环境科学与生态学
小类 | 2 区 环境科学
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Q1 ENVIRONMENTAL SCIENCES
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第一作者机构: [1]Hebei Med Univ, Inst Med & Hlth Sci HeBMU, Ctr Neurosci Res, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Coll Basic Med, Shijiazhuang 050017, Hebei, Peoples R China
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通讯机构: [1]Hebei Med Univ, Inst Med & Hlth Sci HeBMU, Ctr Neurosci Res, Shijiazhuang 050017, Hebei, Peoples R China [6]Hebei Med Univ, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei, Peoples R China [7]Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identificat, Shijiazhuang 050017, Hebei, Peoples R China [*1]Center of Neuroscience Research, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [*2]Center of Neuroscience Research, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China.
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