Exposure to environmental endocrine disruptors (EEDs) could induce high risk of cancer, obesity and depression. Fluorene-9-bisphenol (BHPF), a widely used EED, has been reported to exhibit anti-estrogenic activity and induce insomnia-like behaviors. The potential effects of BHPF exposure on emotional behaviors are still elusive. The present study aimed to investigated the neurobehavioral effects of BHPF exposure intragastrically (0.5, 5 mg kg(-1), i.g.) at different developmental stages by using behavioral tests, including open field test (OFT), novelty-suppressed feeding test (NSF), sucrose preference test (SPT), tail suspension test (TST) and forced swimming test (FST). The results showed that adulthood BHPF exposure significantly induced anxiety- and depression-like behaviors in adult male mice; exposure to BHPF during pregnancy could attenuate depression-like behaviors in female mice. Maternal BHPF exposure reduced spontaneous activity of both male and female adolescent offspring as well as male adult offspring. Besides, maternal BHPF exposure decreased depression-like behaviors in both male and female adolescent offspring, and the female adolescent offspring were more sensitive than male adolescent offspring. Maternal exposure to BHPF decreased depression-like behaviors in male adult offspring; increased depression- and anxiety-like behaviors in female adult offspring. In conclusion, these data indicated that exposure to BHPF could disrupt neurobehaviors to varying degrees at different stages in mice. (C) 2019 Elsevier Ltd. All rights reserved.