机构：[1]Department of Pharmacy, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China[2]Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China[3]Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050091, China[4]Department of General Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China河北医科大学第四医院
Triptolide and fenofibrate are often used together for the treatment of nephrotic syndrome in Chinese clinics. This study investigates the effects of triptolide on the pharmacokinetics of fenofibrate in rats and it potential mechanism. The pharmacokinetics of fenofibrate (20 mg/kg) with or without triptolide pretreatment (2 mg/kg/day for seven days) were investigated. Additionally, the inhibitory effects of triptolide on the metabolic stability of fenofibrate were investigated using rat liver microsome incubation systems. The results indicated that the C-max (35.34 +/- 7.52 vs. 30.43 +/- 6.45 mu g/mL), t(1/2) (6.17 +/- 1.15 vs. 4.90 +/- 0.82 h) and AUC((0-t)) (468.12 +/- 35.84 vs. 416.35 +/- 32.68 mg h L-1) of fenofibric acid decreased significantly (p < .05). The T-max of fenofibric acid increased significantly (p < .05) from 5.12 +/- 0.36 to 6.07 +/- 0.68 h. Additionally, the metabolic stability of fenofibrate was prolonged from 35.8 +/- 6.2 to 48.6 +/- 7.5 min (p < .05) with the pretreatment of triptolide. In conclusion, these results indicated that triptolide could affect the pharmacokinetics of fenofibric acid, possibly by inhibiting the metabolism of fenofibrate in rat liver when they were co-administered.
第一作者机构：[1]Department of Pharmacy, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacy, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China[*1]Department of Pharmacy, the Third Hospital of Hebei Medical University, No. 139, Ziqiang Road, Shijiazhuang 050051, China
推荐引用方式(GB/T 7714)：
Li Tonghui,Liu Jijun,Zheng Yingying,et al.Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism[J].XENOBIOTICA.2019,49(2):211-215.doi:10.1080/00498254.2018.1438685.
APA：
Li, Tonghui,Liu, Jijun,Zheng, Yingying,Yang, Shengchang,Liu, Xun&Li, Xuejing.(2019).Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism.XENOBIOTICA,49,(2)
MLA：
Li, Tonghui,et al."Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism".XENOBIOTICA 49..2(2019):211-215
