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Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Yang, Yaohua[1] * ; Wu, Lang[1] ; Shu, Xiang[1] ; Lu, Yingchang[1] ; Shu, Xiao-Ou[1] ; Cai, Qiuyin[1] ; Beeghly-Fadiel, Alicia[1] ; Li, Bingshan[2] ; Ye, Fei[3] ; Berchuck, Andrew[4] ; Anton-Culver, Hoda[5] ; Banerjee, Susana[6] ; Benitez, Javier[7,8] ; Bjorge, Line[9,10] ; Brenton, James D.[11] ; Butzow, Ralf[12] ; Campbell, Ian G.[13,14] ; Chang-Claude, Jenny[15,16] ; Chen, Kexin[17] ; Cook, Linda S.[18,19] ; Cramer, Daniel W.[20,21,22] ; defazio, Anna[23,24] ; Dennis, Joe[25] ; Doherty, Jennifer A.[26] ; Doerk, Thilo[27] ; Eccles, Diana M.[28] ; Edwards, Digna Velez[29] ; Fasching, Peter A.[30,31] ; Fortner, Renee T.[15] ; Gayther, Simon A.[32] ; Giles, Graham G.[33,34,35] ; Glasspool, Rosalind M.[36] ; Goode, Ellen L.[37] ; Goodman, Marc T.[38] ; Gronwald, Jacek[39] ; Harris, Holly R.[40,41] ; Heitz, Florian[42,43] ; Hildebrandt, Michelle A.[44] ; Hogdall, Estrid[45,46] ; Hogdall, Claus K.[47] ; Huntsman, David G.[48,49,50,51,52] ; Kar, Siddhartha P.[25] ; Karlan, Beth Y.[53] ; Kelemen, Linda E.[54,55] ; Kiemeney, Lambertus A.[56] ; Kjaer, Susanne K.[45,57] ; Koushik, Anita[58,59] ; Lambrechts, Diether[60,61] ; Le, Nhu D.[62] ; Levine, Douglas A.[63,64] ; Massuger, Leon F.[65] ; Matsuo, Keitaro[66,67] ; May, Taymaa[68] ; McNeish, Iain A.[69,70] ; Menon, Usha[71] ; Modugno, Francesmary[72,73,74] ; Monteiro, Alvaro N.[75] ; Moorman, Patricia G.[76] ; Moysich, Kirsten B.[77] ; Ness, Roberta B.[78] ; Nevanlinna, Heli[79] ; Olsson, Hakan[80] ; Onland-Moret, N. Charlotte[81] ; Park, Sue K.[82,83,84] ; Paul, James[36] ; Pearce, Celeste L.[85,86] ; Pejovic, Tanja[87,88] ; Phelan, Catherine M.[75] ; Pike, Malcolm C.[86,89] ; Ramus, Susan J.[90,91] ; Riboli, Elio[92] ; Rodriguez-Antona, Cristina[7,8] ; Romieu, Isabelle[93] ; Sandler, Dale P.[94] ; Schildkraut, Joellen M.[95] ; Setiawan, Veronica W.[96] ; Shan, Kang[97] ; Siddiqui, Nadeem[98] ; Sieh, Weiva[99,100] ; Stampfer, Meir J.[101,102] ; Sutphen, Rebecca[103] ; Swerdlow, Anthony J.[104,105] ; Szafron, Lukasz M.[106] ; Teo, Soo Hwang[107,108] ; Tworoger, Shelley S.[75,109,110] ; Tyrer, Jonathan P.[111] ; Webb, Penelope M.[112] ; Wentzensen, Nicolas[113] ; White, Emily[114,115] ; Willett, Walter C.[20,101,102,116] ; Wolk, Alicja[117,118] ; Woo, Yin Ling[119] ; Wu, Anna H.[96] ; Yan, Li[120] ; Yannoukakos, Drakoulis[121] ; Chenevix-Trench, Georgia[122] ; Sellers, Thomas A.[75] ; Pharoah, Paul D. P.[25,111] ; Zheng, Wei[1] ; Long, Jirong[1，*1] ;
机构： [1]Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, 221 Kirkland Hall, Nashville, TN 37235 USA [2]Vanderbilt Univ, Vanderbilt Genet Inst, Dept Mol Physiol & Biophys, 221 Kirkland Hall, Nashville, TN 37235 USA [3]Vanderbilt Univ, Med Ctr, Dept Biostat, Div Canc Biostat, 221 Kirkland Hall, Nashville, TN 37235 USA [4]Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA [5]Univ Calif Irvine, Genet Epidemiol Res Instl, Dept Epidemiol, Irvine, CA USA [6]Royal Marsden Hosp, Gynaecol Unit, London, England [7]Spanish Natl Canc Res Ctr, CNIO, Human Canc Genet Programme, Madrid, Spain [8]CIBERER, Biomed Network Rare Dis, Madrid, Spain [9]Haukeland Hosp, Dept Gynecol & Obstet, Bergen, Norway [10]Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, Bergen, Norway [11]Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England [12]Univ Helsinki, Helsinki Univ Hosp, Dept Pathol, Helsinki, Finland [13]Peter MacCallum Canc Inst, Melbourne, Vic, Australia [14]Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia [15]German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany [16]Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol Grp, Hamburg, Germany [17]Tianjin Med Univ Canc Inst & Hosp, Dept Epidemiol, Tianjin, Peoples R China [18]Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA [19]Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Calgary, AB, Canada [20]Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA [21]Brigham & Womens Hosp, Obstetr & Gynecol Epidemiol Ctr, 75 Francis St, Boston, MA 02115 USA [22]Harvard Med Sch, Boston, MA USA [23]Univ Sydney, Westmead Inst Med Res, Ctr Canc Res, Sydney, NSW, Australia [24]Westmead Hosp, Dept Gynaecol Oncol, Sydney, NSW, Australia [25]Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England [26]Univ Utah, Dept Populat Hlth Sci, Huntsman Canc Inst, Salt Lake City, UT USA [27]Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany [28]Univ Southampton, Fac Med, Canc Sci Acad Unit, Southampton, Hants, England [29]Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Vanderbilt Genet Inst,Vanderbilt Epidemol Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA [30]Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA [31]Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany [32]Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Bioinformat & Funct Genom, Los Angeles, CA 90048 USA [33]Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia [34]Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia [35]Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia [36]Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland [37]Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA [38]Cedars Sinai Med Ctr, Canc Prevent & Genet Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA [39]Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland [40]Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA [41]Univ Washington, Dept Epidemiol, Seattle, WA USA [42]Dr Horst Schmidt Kliniken Wiesbaden, Dept Gynecol & Gynecol Oncol, Wiesbaden, Germany [43]Huyssens Stiftung Knappschaft GmbH, Kliniken Essen Mitte Evang, Dept Gynecol & Gynecol Oncol, Essen, Germany [44]Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA [45]Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Copenhagen, Denmark [46]Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Copenhagen, Denmark [47]Univ Copenhagen, Rigshosp, Dept Gynecol, Juliane Marie Ctr, Copenhagen, Denmark [48]BC Canc Res Ctr, Dept Mol Oncol, Vancouver, BC, Canada [49]Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada [50]Univ British Columbia, Dept Obstet & Gynaecol, Vancouver, BC, Canada [51]Vancouver Gen Hosp, OVCARE, Vancouver Coastal Hlth Res Ctr, Vancouver, BC, Canada [52]Univ British Columbia, Vancouver, BC, Canada [53]Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA [54]Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA [55]Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA [56]Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands [57]Univ Copenhagen, Rigshosp, Dept Gynaecol, Copenhagen, Denmark [58]Univ Montreal, CHUM Res Ctr CRCHUM, Montreal, PQ, Canada [59]Univ Montreal, Dept Med Social & Prevent, Montreal, PQ, Canada [60]Univ Leuven, VIB Ctr Canc Biol, VIB, Dept Human Genet, Leuven, Belgium [61]Univ Leuven, Lab Translat Genet, Dept Human Genet, Leuven, Belgium [62]BC Canc Agcy, Canc Control Res, Vancouver, BC, Canada [63]Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10021 USA [64]NYU, Langone Med Ctr, Laura & Isaac Pearlmutter Canc Ctr, Gynecol Oncol, New York, NY USA [65]Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Gynaecol, Nijmegen, Netherlands [66]Aichi Canc Ctr, Res Inst, Div Mol Med, Nagoya, Aichi, Japan [67]Nagoya Univ, Grad Sch Med, Dept Epidemiol, Nagoya, Aichi, Japan [68]Univ Hlth Network, Princess Margaret Hosp, Div Gynecol Oncol, Toronto, ON, Canada [69]Imperial Coll London, Dept Surg & Canc, London, England [70]Univ Glasgow, Beatson Inst Canc Res, Wolfson Wohl Canc Res Ctr, Inst Canc Sci, Glasgow, Lanark, Scotland [71]UCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit, London, England [72]Womens Canc Res Ctr, Magee Womens Res Inst, Pittsburgh, PA USA [73]Hillman Canc Ctr, Pittsburgh, PA USA [74]Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Pittsburgh, PA USA [75]H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA [76]Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA [77]Roswell Pk Canc Inst, Div Canc Prevent & Control, Buffalo, NY 14263 USA [78]Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, UTHlth, Houston, TX 77030 USA [79]Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland [80]Lund Univ, Clin Sci, Dept Canc Epidemiol, Lund, Sweden [81]Univ Utrecht, UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands [82]Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea [83]Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Seoul, South Korea [84]Seoul Natl Univ, Canc Res Inst, Seoul, South Korea [85]Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA [86]Univ Southern Calif, Keck Sch Med, Norris Comprehen Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA [87]Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA [88]Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA [89]Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA [90]Univ New South Wales Sydney, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia [91]Garvan Inst Med Res, Kinghorn Canc Ctr, Sydney, NSW, Australia [92]Imperial Coll London, London, England [93]IARC, WHO, Nutrit & Metab Sect, Lyon, France [94]NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA [95]Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA [96]Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA [97]Hebei Med Univ, Hosp 4, Dept Obstet & Gynaecol, Shijiazhuang, Hebei, Peoples R China [98]Glasgow Royal Infirm, Dept Gynaecolo Oncol, Glasgow, Lanark, Scotland [99]Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA [100]Icahn Sch Med Mt Sinai, Dept Hlth Sci & Policy, New York, NY 10029 USA [101]Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA [102]Harvard Med Sch, Boston, MA USA [103]Univ S Florida, Coll Med, Epidemiol Ctr, Tampa, FL USA [104]Inst Canc Res, Div Genet & Epidemiol, London, England [105]Inst Canc Res, Div Breast Canc Res, London, England [106]Maria Sklodowska Curie Inst, Oncol Ctr, Dept Immunol, Warsaw, Poland [107]Canc Res Malaysia, Subang Jaya, Selangor, Malaysia [108]Univ Malaya, Med Ctr, Canc Res Inst, Breast Canc Res Unit, Kuala Lumpur, Malaysia [109]Harvard TH Chan Sch Publ Hlth, Res Inst, Boston, MA USA [110]Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA [111]Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England [112]QIMR Berghofer Med Res Inst, Populat Hlth Dept, Brisbane, Qld, Australia [113]NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA [114]Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA [115]Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA [116]Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA [117]Karolinska Inst, Inst Environm Med, Stockholm, Sweden [118]Uppsala Univ, Dept Surg Sci, Uppsala, Sweden [119]Univ Malaya, Med Ctr, Dept Obstet & Gynaecol, Kuala Lumpur, Malaysia [120]Hebei Med Univ, Hosp 4, Dept Mol Biol, Shijiazhuang, Hebei, Peoples R China [121]NCSR Demokritos, INRASTES, Mol Diagnos Lab, Athens, Greece [122]QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia [123]Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, 2525 West End Ave,Suite 800, Nashville, TN 37203 USA
出处：
DOI： 10.1158/0008-5472.CAN-18-2726
ISSN：

摘要：
DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 x 10(-7). Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. Significance: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.

基金：
Breast Cancer Now; Institute of Cancer Research (ICR); NHS; Vanderbilt CTSA from NCATS/NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000445]; Cancer Research UKCancer Research UK; University of CambridgeUniversity of Cambridge; National Institute for Health Research Cambridge Biomedical Research CentreNational Institute for Health Research (NIHR); Innovative Research Team in University (PCSIRT) in China [IRT1076]; Gynecologic Cancer Center of Excellence [W81XWH-11-2-0131]; Dutch Cancer SocietyKWF Kankerbestrijding [EMC 2014-6699, EMC 20146699]; Helsinki University Research Fund; JSPS KAKENHI grantMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI); Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI); National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of KoreaMinistry of Health & Welfare, Republic of Korea [HI16C1127, 0920010]; Malaysian Ministry of Higher Education (UM.C/HIR/MOHE/06); Cancer Research Initiatives Foundation; VicHealth; Cancer Council VictoriaCanadian Institutes of Health Research (CIHR)Cancer Council Victoria; Australian NHMRC grantsNational Health and Medical Research Council of Australia [209057, 251553, 504711]; NCI designated Comprehensive Cancer Center [P30-CA076292]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P50 CA159981, R01CA126841, R37-CA070867, U19-CA148112, R01-CA149429, R01-CA058598, RO1-CA142081, R01-CA063678, R01-CA074850, R01-CA080742, R01CA112523, R01-CA87538, R01-CA58598]; Intramural Research Program of the NIH, National Institute of Environmental Health SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [Z01-ES044005, Z01-ES049033]; National Health Research and Development Program, Health Canada [6613-1415-53]; NIH, NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [CA58860]; Lon V Smith Foundation grant [LVS-39420]; National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [310670, 628903]; Cancer Institute NSW grants [12/RIG/1-17, 15/RIG/1-16]; Department of Medicine at Vanderbilt University Medical Center; Ovarian Cancer Research Fund; US National Cancer Institute GAME-ON Post-GWAS Initiative [U19-CA148112]; Wellcome TrustWellcome Trust [076113]; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR) [MOP-86727]; Canadian Institutes of Health Research (Ovarian Cancer Research Fund)Canadian Institutes of Health Research (CIHR); European CommissionEuropean CommissionEuropean Commission Joint Research Centre [223175 - HEALTH-F2-2009-223175]; U.S. Army Medical Research and Materiel CommandU.S. Army Medical Research & Materiel Command (USAMRMC) [DAMD17-01-1-0729]; National Health & Medical Research Council of AustraliaNational Health and Medical Research Council of Australia [199600, 400413, 400281]; Cancer Council of New South WalesCancer Council New South Wales; Cancer Council of VictoriaCanadian Institutes of Health Research (CIHR)Cancer Council Victoria; Cancer Council of QueenslandCancer Council Queensland; Cancer Council of South AustraliaCancer Council South Australia; Cancer Council of TasmaniaCancer Council Tasmania; Cancer Foundation of Western AustraliaCancer Council Western Australia [191, 211, 182]; Ovarian Cancer Australia; Peter MacCallum Foundation; ELAN Funds of the University of Erlangen-Nuremberg; National Kankerplan; Breast Cancer Now, Institute of Cancer Research; Vanderbilt CTSA grant from the NIH/National Center for Advancing Translational Sciences (NCATS) [ULTR000445]; National Institutes of Health Research Cambridge Biomedical Research Centre; Cancer Research UK Cambridge Cancer Centre; Innovative Research Team at the University (PCSIRT) in China [IRT1076]; Instituto de Salud Carlos IIIInstituto de Salud Carlos III [PI 12/01319]; Ministerio de Economia y Competitividad (SAF2012); Department of DefenseUnited States Department of Defense [W81XWH-11-2-0131, DAMD17-02-1-0666, DAMD17-02-1-0669]; European Commission (DG-SANCO)European CommissionEuropean Commission Joint Research Centre; International Agency for Research on Cancer; Danish Cancer Society (Denmark)Danish Cancer Society; Ligue Contre le Cancer (France); Institut Gustave Roussy (France); Mutuelle Generale de l'Education Nationale (France); Institut National de la Sante et de la Recherche Medicale (INSERM; France)Institut National de la Sante et de la Recherche Medicale (Inserm); German Cancer Aid (Germany)Deutsche Krebshilfe; German Cancer Research Center (DKFZ) (Germany); Federal Ministry of Education and Research (BMBF; Germany)Federal Ministry of Education & Research (BMBF); Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-ItalyAssociazione Italiana per la Ricerca sul Cancro (AIRC); National Research Council (Italy)Consiglio Nazionale delle Ricerche (CNR); Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)Netherlands Government; Netherlands Cancer Registry (NKR) (The Netherlands)Netherlands Government; LK Research Funds (The Netherlands)Netherlands Government; Dutch Prevention Funds (The Netherlands)Netherlands Government; Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)Netherlands Government; World Cancer Research Fund (WCRF) (The Netherlands)Netherlands GovernmentWorld Cancer Research Fund International (WCRF); Statistics Netherlands (The Netherlands)Netherlands Government; Nordforsk (Norway); Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS) (Spain)Instituto de Salud Carlos III [PI13/00061, PI13/01162]; Regional Government of Andalucia (Spain)Junta de Andalucia; Regional Government of Asturias (Spain); Regional Government of Basque Country (Spain); Regional Government of Murcia (Spain); Regional Government of Navarra (Spain); ISCIII RETIC (Spain)Instituto de Salud Carlos III [RD06/0020]; Swedish Cancer Society (Sweden)Swedish Cancer Society; Swedish Research Council (Sweden)Swedish Research Council; County Council of Skane (Sweden); County Council of Vasterbotten (Sweden); Cancer Research UK (United Kingdom)Cancer Research UK [14136, C570/A16491, C8221/A19170]; Medical Research Council (United Kingdom)Medical Research Council UK (MRC) [1000143, MR/M012190/1]; German Federal Ministry of Education and Research, Programme of Clinical Biomedical Research [01 GB 9401]; German Cancer Research Center (DKFZ)Helmholtz Association; European Union (European Social Fund -ESF)European Union (EU)European Social Fund (ESF); Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) -Research Funding Program of the General Secretariat for Research Technology. Investing in knowledge society through the European Social Fund [SYN11_10_19 NBCA]; Roswell Park Cancer Institute Alliance Foundation [P30 CA016056]; Rudolf-Bartling Foundation; NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [K07-CA080668, R01-CA95023, P50-CA159981, MO1-RR000056, R01-CA126841]; Ministry of Health, Labour and WelfareMinistry of Health, Labour and Welfare, Japan; American Cancer Society Early Detection ProfessorshipAmerican Cancer Society [SIOP-06-258-01-COUN]; National Center for Advancing Translational Sciences (NCATS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000124]; Swedish Cancer SocietySwedish Cancer Society; Swedish Research CouncilSwedish Research Council; Beta Kamprad Foundation; Mayo Foundation; Minnesota Ovarian Cancer Alliance; Fred C. and Katherine B. Andersen Foundation; Fraternal Order of Eagles; NCI, Bethesda, MDUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01-CA61107]; Danish Cancer Society, Copenhagen, DenmarkDanish Cancer Society [94 222 52]; Mermaid I project; Malaysian Ministry of Higher Education (UM.C/HlR/MOHE/06); National Health and Medical Research Council of Australia (NHMRC)National Health and Medical Research Council of Australia [209057, 251533, 396414, 504715]; DOD Ovarian Cancer Research Program [W81XWH-07-0449]; Moffitt Cancer Center; Merck PharmaceuticalsMerck & Company; state of Florida; Hillsborough County; city of Tampa; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [NIH-K07 CA095666, R01-CA83918, NIH-K22-CA138563, P30-CA072720]; Cancer Institute of New Jersey; Helse Vest; Norwegian Cancer SocietyNorwegian Cancer Society; Research Council of NorwayResearch Council of Norway; Radboud University Medical Centre; National Health and Medical Research Council (NHMRC) of AustraliaNational Health and Medical Research Council of Australia [APP1025142]; Brisbane Women's Club; OHSU Foundation; NIH/NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [1 R01CA160669-01A1]; Intramural Research Program of the National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI); Pomeranian Medical University; Canadian Cancer Society; Cancer Research Society GRePEC Program; National Health and Medical Research Council of AustraliaNational Health and Medical Research Council of Australia; Royal Marsden HospitalRoyal Society of New ZealandMarsden Fund (NZ); Cancer Research UKCancer Research UK [C490/A10119 C490/A10124, C536/A13086, C536/A6689, C490/A6187]; UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge; NIH, National Institute of Environmental Health SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [Z01-ES049033, Z01 ES044005]; Imperial Experimental Cancer Research Centre [C1312/A15589]; Swedish Cancer foundation; WeCanCureCancer; arKampMotCancer foundation; NIH (NCI) grant [R37-CA070867]; American Cancer SocietyAmerican Cancer Society [CRTG-00-196-01-CCE]; Celma Mastery Ovarian Cancer Foundation; Princess Margaret Cancer Centre Foundation Bridge for the CureUniversity of Toronto; Eve Appeal (The Oak Foundation); National Institute for Health Research University College London Hospitals Biomedical Research Centre; California Cancer Research Program [00-01389V-20170, 2II0200]; BC Cancer Foundation; VGH & UBC Hospital Foundation; National Health and Medical Research Council of AustraliaNational Health and Medical Research Council of Australia [310670, 628903]; National Science Centren [N N301 5645 40]; Maria Sklodowska-Curie Memorial Cancer Center; Institute of Oncology, Warsaw, Poland; [1S10RR025141-01]; [ERC-2009-AdG 232997]; [ERC-2011-AdG 294576]; [P01CA17054]; [P30CA14089]; [R01CA61132]; [N01PC67010]; [R03CA113148]; [R03CA115195]; [N01CN025403]; [UM1 CA186107]; [P01 CA87969]; [R01 CA49449]; [R01-CA67262]; [UM1 CA176726]; [N01-CN-55424]; [N01-PC-67001]; [R01-CA122443]; [P30-CA15083]; [P50-CA136393]; [CA54281]; [CA164973]; [CA63464]; [R01-CA76016]; [R01-CA106414-A2]; [R01 CA063678]; [R01 CA063682]; [R01-CA058860]; [K05-CA154337]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P50CA136393, P30CA016056, P30CA015083, P30CA014089, P30CA016056, P30CA015083, P30CA076292, P30CA072720, P30CA016056, P30CA016056, P30CA076292, P30CA014089, P30CA076292, 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States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000445] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [ZIAES044005, ZIAES044005, ZIAES044005] Funding Source: NIH RePORTER
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 肿瘤学
JCR分区：
出版当年[2019]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, 221 Kirkland Hall, Nashville, TN 37235 USA
通讯作者：
通讯机构： [1]Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, 221 Kirkland Hall, Nashville, TN 37235 USA [*1]Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN 37203-1738
推荐引用方式(GB/T 7714)：
Yang Yaohua,Wu Lang,Shu Xiang,et al.Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk[J].CANCER RESEARCH.2019,79(3):505-517.doi:10.1158/0008-5472.CAN-18-2726.
APA：
Yang, Yaohua,Wu, Lang,Shu, Xiang,Lu, Yingchang,Shu, Xiao-Ou...&Long, Jirong.(2019).Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.CANCER RESEARCH,79,(3)
MLA：
Yang, Yaohua,et al."Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk".CANCER RESEARCH 79..3(2019):505-517

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