机构：[1]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China[2]Hebei Med Univ, Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China河北医科大学第四医院[3]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Oncol, Shanghai 201399, Peoples R China
Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.
基金：
National Natural Science Foundation of China (grant No.
81572518 & 81372750) to T.Y., and International
Technology Cooperation Project of Hebei Provincial
Department of Science & Technology (grant
No: 13397708D) to Z.Y.Z.
第一作者机构：[1]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China[3]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Oncol, Shanghai 201399, Peoples R China[*1]Department of Oncology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.[*2]Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Shanghai 201399, China.
推荐引用方式(GB/T 7714)：
Gao Lili,Zhang Zhenya,Zhang Peng,et al.Role of canonical Hedgehog signaling pathway in liver[J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES.2018,14(12):1636-1644.doi:10.7150/ijbs.28089.
APA：
Gao, Lili,Zhang, Zhenya,Zhang, Peng,Yu, Minghua&Yang, Tao.(2018).Role of canonical Hedgehog signaling pathway in liver.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14,(12)
MLA：
Gao, Lili,et al."Role of canonical Hedgehog signaling pathway in liver".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14..12(2018):1636-1644
生物学