机构：[1]Research Center, The Fourth Hospital of Hebei Medical University, 050017Shijiazhuang, Hebei, People’s Republic of China河北医科大学第四医院[2]Animal Center, The FourthHospital of Hebei Medical University, 050017 Shijiazhuang, Hebei, People’sRepublic of China[3]Department of Mathematics, Hebei University of Scienceand Technology, 050018 Shijiazhuang, People’s Republic of China[4]TumorResearch Institute, The Fourth Hospital of Hebei Medical University, 050017Shijiazhuang, Hebei, People’s Republic of China河北医科大学第四医院
Accumulating evidences indicate that microRNAs (miRNAs) play vital roles in multiple diseases, including cancer. In the present study, we showed that miR-6775-3p plays a tumor suppressive role in esophageal squamous cell carcinoma (ESCC). High expression miR-6775-3p is associated with good clinical outcomes of ESCC patients. Over-expression of miR-6775-3p inhibited tumor growth and liver metastasis of ESCC xenograft tumors. Enforced expression of miR-6775-3p inhibited ESCC cell proliferation, migration, and invasion. KEGG pathway analysis revealed that miR-6775-3p was associated with the genes on "pathway in cancer". Mechanically, miR-6775-3p inhibited the expression of tumor antigens MAGE-A family through direct binding the 3'UTR region of MAGE-A mRNAs, and attenuated MAGE-A-inhibited transcriptional activity of tumor suppressor p53. In addition, miR-6775-3p also directly inhibits its host gene SLC7A5 which has been reported to play oncogenic roles in cancer progression. Interestingly, miR-6775-3p and its host gene SLC7A5 were directly transcriptionally induced by p53. Thus, for the first time, our study proposed a novel positive feedback regulation between miR-6775-3p and p53 via MAGE-A family, which plays crucial role in ESCC progression.
基金：
National Natural Science Foundation of China
(No. 81001178), and Natural Science Foundation of Hebei Province, China (No.
H2016206410). The authors would like to greatly appreciate Dr. Qianglin Duan,
a skilled English proofreader from Tongji University for paper revision.
第一作者机构：[1]Research Center, The Fourth Hospital of Hebei Medical University, 050017Shijiazhuang, Hebei, People’s Republic of China
通讯作者：
通讯机构：[1]Research Center, The Fourth Hospital of Hebei Medical University, 050017Shijiazhuang, Hebei, People’s Republic of China[4]TumorResearch Institute, The Fourth Hospital of Hebei Medical University, 050017Shijiazhuang, Hebei, People’s Republic of China
推荐引用方式(GB/T 7714)：
Meng Lingjiao,Liu Fei,Ju Yingchao,et al.Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins[J].CELL DEATH & DISEASE.2018,9:doi:10.1038/s41419-018-1119-3.
APA：
Meng, Lingjiao,Liu, Fei,Ju, Yingchao,Ding, Pingan,Liu, Sihua...&Sang, Meixiang.(2018).Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins.CELL DEATH & DISEASE,9,
MLA：
Meng, Lingjiao,et al."Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins".CELL DEATH & DISEASE 9.(2018)
生物学